Prevalence of allele variants of ADAM33 (rs2280090) and ADRB2 (rs1042714) in Siberian populations

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The article addressed to the study of polymorphic variants of the rs2280090 ADAM33 and rs1042714 ADRB2 genes associated with a predisposition to bronchial asthma in the population of Eastern Siberia (Russian), Khakassia (Khakass) and Tuva (Tuvans). It was found that the AG genotype and the A allele of rs2280090 ADAM33 are more common among Russians compared with Tuvans. Also it was detected that the G rs1042717 ADRB2 allele is significantly more common in Russians relative to Khakas, while the prevalence of the GG genotype is higher in Tuvans compared to Khakas. The findings highlight the importance of ethnic differences in predisposition to bronchial asthma and may be useful for developing strategies for the prevention and treatment of this disease.

作者简介

K. Afonicheva

Scientific Research Institute of Medical Problems of the North – a Separate Division of Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences

Email: smarinv@yandex.ru
Krasnoyarsk, 660022 Russia

S. Tereshchenko

Scientific Research Institute of Medical Problems of the North – a Separate Division of Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences

编辑信件的主要联系方式.
Email: smarinv@yandex.ru
Krasnoyarsk, 660022 Russia

M. Smolnikova

Scientific Research Institute of Medical Problems of the North – a Separate Division of Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences

Email: smarinv@yandex.ru
Krasnoyarsk, 660022 Russia

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