MorphologyMorphology1026-35432949-2556Eco-Vector11987910.17816/morph.119879Research ArticleThe analysis of histological features and morphometric parameters of the ovaries in absenсe epilepsySadrtdinovaIndira I.<p>Cand. Sci. (Biol.), Associate Professor</p>indira.ildarovna@mail.ruhttps://orcid.org/0000-0002-4951-0189KhismatullinaZuhra R.<p>Dr. Sci. (Biol.), Associate Professor</p>hismatullinazr@mail.ruhttps://orcid.org/0000-0002-3209-5265Ufa University of Science and Technology22052023160285922312202225012023Copyright © 2023, Eco-Vector2023<p><strong><em>BACKGROUND: </em></strong>Absence epilepsy is one of the most common epileptic syndromes and is more common in girls. Often in adolescence, generalized tonic-clonic seizures (up to 50%) join. In women suffering from epilepsy, reproductive dysfunction is often noted. In this regard, it seems relevant to study the morphofunctional state of the ovaries in absence epilepsy.</p>
<p><strong><em>AIM: </em></strong>Assessment of morphological and morphometric parameters of the ovaries in absence epilepsy.</p>
<p><strong><em>MATERIALS AND METODS:</em></strong> Using histological and morphometric methods, the ovaries of Wistar and WAG/Rij rats (a genetic model of human absence epilepsy) were studied.</p>
<p><strong><em>RESULTS: </em></strong>In WAG/Rij rats, destruction of the cortical and medulla of the ovary was found: the layer of granulosa cells surrounding the oocyte had a looser structure compared to the norm, destructive changes in the follicular epithelium and apoptotic death of granulosa cells were observed. Morphometric analysis showed that in WAG/Rij rats the weight of the ovaries was 2 times less than in Wistar rats: 37.300.93 mg versus 55.842.36 mg. The thickness of the epithelial layer was 7.810.25 m, which is 26.2% less than in Wistar rats (<em>p</em> 0.05). The ovarian follicles of WAG/Rij rats were irregular in shape, smaller in diameter and area, and the numerical density of all types of follicles was lower compared to Wistar rats, which indicates a violation of ovulation processes.</p>
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