MorphologyMorphologyМорфология1026-35432949-2556Eco-Vector39855710.17816/morph.398557ArticlesСтатьиSTRUCTURAL CHANGES OF SOME ORGANS IN RATS AFTER A SINGLE INTRAVENOUS INJECTION OF MAGNETITE NANOPARTICLESСТРУКТУРНЫЕ ИЗМЕНЕНИЯ НЕКОТОРЫХ ОРГАНОВ КРЫС ПОСЛЕ ОДНОКРАТНОГО ВНУТРИВЕННОГО ВВЕДЕНИЯ НАНОРАЗМЕРНОГО МАГНЕТИТАMil'toI VМильтоИ В

Кафедра морфологии и общей патологии (зав. - проф. И. В. Суходоло); Сибирский государственный медицинский университет

milto_bio@mail.ruSukhodoloI VСуходолоИ В

Кафедра морфологии и общей патологии (зав. - проф. И. В. Суходоло); Сибирский государственный медицинский университет

MiltoI VSukhodoloI VСибирский государственный медицинский университет150620121412NO2 (2012)№2 (2012)495309052023Copyright ©; 2012, Eco-VectorCopyright ©; 2012, Эко-Вектор2012Eco-VectorЭко-Векторhttps://j-morphology.com/1026-3543/article/view/398557

The aim of this investigation was to study the morphological changes of liver, lung, kidneys and spleen as well as of the cells of mononuclear pahagocyte system in 60 rats 1-40 days after a single intravenous injection of a suspension of magnetite nanoparticles. Moderate hemodynamic disturbances and focal necrotic changes were detected in the hepatic and renal parenchyma. In the lungs and spleen, only hemodynamic disturbances were found. The degree of morphological changes in rat liver, lungs, kidneys and spleen was decreased by day 10. Using Perls histochemical method, the accumulation of nanoparticles was detected in the cells of mononuclear phagocyte system of the organs studied.

Цель работы состояла в выявлении морфологических изменений печени, легкого, почек и селезенки, включая клетки системы мононуклеарных фагоцитов в этих органах, у 60 крыс через 1-40 сут после однократного внутривенного введения суспензии наноразмерных частиц магнетита. Описаны умеренные гемодинамические расстройства и фокальные некротические изменения паренхимы печени и почек. В легких и селезенке показаны только гемодинамические нарушения. Выраженность морфологических изменений в печени, легких, почках и селезенке у крыс снижается к 40-м суткам. Гистохимическим методом Перлса выявлено накопление частиц наноматериала в клетках системы мононуклеарных фагоцитов исследованных органов.

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