MorphologyMorphologyМорфология1026-35432949-2556Eco-Vector39880010.17816/morph.398800ArticlesСтатьиReview ArticleTHE ROLE OF E-CADHERIN CELL ADHESION MOLECULE IN HUMAN ONTOGENESIS IN NORM AND PATHOLOGYРОЛЬ МОЛЕКУЛЫ КЛЕТОЧНОЙ АДГЕЗИИ Е-КАДГЕРИНА В ОНТОГЕНЕЗЕ ЧЕЛОВЕКА В НОРМЕ И ПАТОЛОГИИZasadkevichYu. M.ЗасадкевичЮлия Михайловна

кафедра гистологии, цитологии и эмбриологии

zasadkevich@selltechnologies.ruSazonovS. V.СазоновСергей Владимирович

кафедра гистологии, цитологии и эмбриологии

prof-ssazonov@yandex.ruInstitute of Medical Cell Technologies Centre of Rendering the Specialized Medical Aid to the PopulationУральский государственный медицинский университет Минздрава РФ151020141465VOL 146, NO5 (2014)ТОМ 146, №5 (2014)788209052023Copyright ©; 2014, Eco-VectorCopyright ©; 2014, Эко-Вектор2014Eco-VectorЭко-Векторhttps://j-morphology.com/1026-3543/article/view/398800

E-cadherin is one of the most important cell adhesion molecules, which plays a key role in embryogenesis and adult tissues under normal conditions and during tumor development. Molecules of E-cadherin are located at the epitheliocyte surface and take part in the adhesion contacts formation which are a characteristic feature of epithelial tissues. The role of E-cadherin is not only in the maintenance of intercellular adhesion, but also in provision of cell proliferation and differentiation through participation in the realization of a number of signaling pathways, the main of which is the canonical Wnt signaling pathway. This review provides basic information regarding the role of E-cadherin in human ontogenesis in norm and pathology

Е-кадгерин - одна из наиболее значимых молекул клеточной адгезии, играющих ключевую роль в эмбриогенезе и тканях взрослого организма в норме и при развитии опухоли. Молекулы Е-кадгерина локализуются на поверхности эпителиоцитов, участвуя в образовании адгезионных контактов, являющихся характерной особенностью эпителиальных тканей. Роль Е-кадгерина заключается не только в поддержании межклеточной адгезии, но и в обеспечении клеточной пролиферации и дифференцировки за счет участия в реализации ряда сигнальных путей, главным из которых является канонический сигнальный путь Wnt. В данном обзоре приведены основные сведения, касающиеся значения Е-кадгерина в онтогенезе человека в норме и патологии.

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