MorphologyMorphologyМорфология1026-35432949-2556Eco-Vector39880110.17816/morph.398801ArticlesСтатьиReview ArticleREGULATION OF HAIR FOLLICLE CYCLEРЕГУЛЯЦИЯ ЦИКЛИЧЕСКОЙ АКТИВНОСТИ ВОЛОСЯНЫХ ФОЛЛИКУЛОВGoryachkinaV. L.ГорячкинаВалерия Львовна

кафедра гистологии, цитологии и эмбриологии

IvanovaM. Yu.ИвановаМарина Юрьевна

кафедра гистологии, цитологии и эмбриологии

ivanova_m_y@mail.ruTsomartovaD. A.ЦомартоваДибахан Асланбековна

кафедра гистологии, цитологии и эмбриологии

dtsomartova@mail.ruKartashkinaN. L.КарташкинаНаталия Левоновна

кафедра гистологии, цитологии и эмбриологии

knlmma@mail.ruKuznetsovS. L.КузнецовСергей Львович

кафедра гистологии, цитологии и эмбриологии

vakmedbiol@rambler.ruI. M. Sechenov First Moscow State Medical UniversityПервый Московский государственный медицинский университет им. И. М. Сеченоваru1510201420141465VOL 146, NO5 (2014)ТОМ 146, №5 (2014)838709052023Received:09052023Published:15102014Copyright ©; 2014, Eco-VectorCopyright ©; 2014, Эко-Вектор2014Eco-VectorЭко-Векторhttps://j-morphology.com/1026-3543/article/view/398801

This review is devoted to the control of hair growth. The hair follicle undergoes cyclic transformation from the resting phase (telogen) to the growth phase (anagen). The latter phase is characterized by rapid proliferation of follicular keratinocytes and elongation and thickening of the hair shaft. The regression phase (catagen) leads to the involution of the hair follicle. These cyclic changes include rapid remodeling of both the epithelial and the dermal components. They are controlled by numerous different factors: sex hormones, neurotrophins, FGF, TGF, BMP, VEGF, Sonic Hedgehog, and other signaling pathways.

В обзоре представлена информация о регуляции цикличности роста волоса. Волосяной фолликул подвергается циклическим изменениям от фазы покоя (телоген) до фазы роста (анаген). Последняя характеризуется быстрой пролиферацией фолликулярных кератиноцитов, удлинением и утолщением волосяного стержня. Следующая фаза - катаген приводит к инволюции волосяного фолликула. В процессе этих циклических изменений происходит быстрое ремоделирование как эпителиальных, так и дермальных компонентов под контролем множества различных факторов: половых гормонов, нейротрофинов, фактора роста фибробластов (FGF), трансформирующего фактора роста (TGF), костного морфогенетического белка (BMP), фактора роста сосудистого эндотелия (VEGF), сигнальных молекул (Sonic Hedgehog) и др.

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