MorphologyMorphologyМорфология1026-35432949-2556Eco-Vector39923110.17816/morph.399231ArticlesСтатьиJUXTAORAL ORGAN OF CHIEVITZОКОЛОРОТОВОЙ ОРГАН ХИВИЦАBykovV LБыковВ Л

Кафедра гистологии, цитологии и эмбриологии (зав. - проф. В.Л. Быков) Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова; Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова

BykovV L

I.P. Pavlov St. Petersburg State Medical University

Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаI.P. Pavlov St. Petersburg State Medical University151220091366NO6 (2009)№6 (2009)849509052023Copyright ©; 2009, Eco-VectorCopyright ©; 2009, Эко-Вектор2009Eco-VectorЭко-Векторhttps://j-morphology.com/1026-3543/article/view/399231

This review presents the analysis of the systematized data on human juxtaoral organ (JOO) development, structure and function based on the results of classical and recent morphological studies. JOO morphogenesis is traced, including the appearance of its anlage at the bottom of the primitive mouth, epithelial invagination into the mesenchyme, JOO detachment from the oral epithelium, its innervation, connective tissue capsule formation, and final maturation. The analysis of the results of macroscopical, histological, electron microscopical, histochemical and immunohistochemical studies is presented, suggesting high metabolic and synthetic activity of its epithelium, which expresses several neural markers, and emphasizing a rich innervation of both its epithelial and stromal components. The findings supporting the concepts of JOO secretory and mechanosensory functions, are examined. The data on the differential diagnosis between JOO and tumoral processes are discussed, as well as the pathological changes of JOO it self and their significance for the diagnosis of the diseases.

Обзор литературы содержит анализ систематизированных сведений о развитии, строении и функции околоротового (юкстаорального) органа (ОРО) человека с учетом данных как классических, так и современных морфологических исследований. Прослежен морфогенез ОРО, включающий появление его закладки на дне первичного рта, инвагинации эпителия в мезенхиму, отделение ОРО от эпителия полости рта, его иннервацию, формирование соединительнотканной капсулы и окончательное созревание. Представлен анализ результатов макроскопического, гистологического, электронномикроскопического, гистохимического и иммуногистохимического исследования ОРО, который указывает на высокую метаболическую и синтетическую активность его эпителия, экспрессирующего ряд нейральных маркеров, богатую иннервацию эпителиального и стромального компонентов. Рассматриваются данные, лежащие в основе представлений о секреторной и механорецепторной функциях ОРО. Приводятся сведения о дифференциальной диагностике между ОРО и опухолевыми процессами, а также о патологических изменениях самого ОРО и их значении в диагностике заболеваний.

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