Morphology
https://j-morphology.com/1026-3543
<p>Peer-review medical and biological journal.</p> <p><strong>Editor-in-Chief</strong>: Ass. professor Roman V. Deev, MD, Cand. Sci. (Med.).</p> <p><strong>Indexation</strong>: Russian Science Citation Index, Google Scholar, Ulrich's Periodicals Directory, Dimensions, Crossref.</p> <p><strong>Open Access & Publication frequency</strong>: Hybrid — Subscription & Open Access; quarterly issuing.</p> <p><strong>Peer-Review & APC</strong>: double blind; no obligatory article processing charge.</p> <p><strong>ISSN</strong>: 1026-3543 (Print) <strong>ISSN</strong>: 2949-2556 (Online)</p>
Eco-Vector
ru-RU
Morphology
1026-3543
<p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal exclusive license to first publication.</li> <li>Authors are able to distribute the manuscript and/or the article in accordance with Self-Archiving policy of the journal (<a href="/1026-3543/about/editorialPolicies#authorSelfArchivePolicy" target="_blank" rel="noopener">see details</a>).</li> <li>The manuscript can be accepted for publication only by decision of the Editor-in-Chief and the Editorial board of the journal in accordance with the Manuscript stelection policy of the journal (<a href="/1026-3543/about/editorialPolicies#peerReviewProcess" target="_blank" rel="noopener">see details</a>).</li> <li>Published Article will be distributed in print and electronic version an will be available under subscription with Delayed Open Access or in Immediate Open Access under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (<a href="https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ru" target="_blank" rel="noopener">CC BY-NC-ND 4.0</a>). The access model depends on the publisher's decision or is determined by a separate Open Access publishing agreement with the authors.</li> </ol> <p>An exclusive license for publication granted by authors allows the publisher to use the article in the following ways:</p> <ul> <li>Reproduction of the Article or its sections or parts, as well as the metadata of the Article in any languages, in any material form, including on paper and electronic media, as a separate work in the journal and/or databases (local or in the Internet) of the publisher and/or other persons, at the discretion of the publisher;</li> <li>Distribution of the Article or its sections or parts, as well as the metadata of the Article in any languages, on any medium as part of the journal and/or databases of the publisher or other persons, at the discretion of the publisher, or as an independent work around the world whether on Open-Access terms or for a fee without remuneration to the Author;</li> <li>Making the Article or any of its sections or parts, as well as the Article’s metadata in any languages, publicly available in such a way that any person can access the Article from any place, including via the Internet, and at any time of their own choosing;</li> <li>Granting permission/s for the use of the Article or its sections or parts, as well as its metadata in any languages, to third parties with notice to the Author made by posting relevant information on the journal’s website, without paying remuneration to the Author;</li> <li>Processing the Article (i.e., editing, correcting, annotating, tagging, translating to any languages, typesetting) and using the revised (translated) Article in the aforementioned ways.</li> </ul> <p>Other rights not directly transferred to the publisher under this License Agreement, including patent rights to any process, method etc., described by the Authors in the manuscript, as well as trademark rights, are reserved for the Authors.</p> <p>All the Copyright statements for authors are present in the standart Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical <strong>'Morphology'</strong>.</p> <p>- <a href="https://j-morphology.com/files/journals/132/doc/Copyrightagreement_final_eng_exclusive_v.2022.09.29.pdf" target="_blank" rel="noopener">DOWNLOAD</a> the print-version of the License Agreement.</p> <div><details> <summary><strong>READ the details online</strong> (tap to see in details)</summary> <p><strong>Author’s license agreement (public offer) on the publication of an article in a scholarly journal </strong><br><strong>“Morphology”</strong></p> <p>Eco-Vector, represented by its CEO Evgeniy Schepin and acting on the basis of the Charter (hereinafter referred to as the Publisher), on the one hand, offers an indefinite circle of persons (hereinafter referred to as the Author), and on the other hand, hereinafter jointly referred to as the Parties, to execute this agreement (hereinafter referred to as the Agreement) on the publication of scientific article (hereinafter referred to as the Article) in a scholarly journal <strong>“Morphology”</strong> (further-the Journal) in accordance with the conditions stated below.</p> <p> </p> <p><strong>I. General Provisions</strong></p> <ol> <li>This Agreement, in accordance with clause 2 of Article 437 of the Civil Code of the Russian Federation, is a public offer (hereinafter referred to as the Offer) requiring full and unconditional acceptance (Acceptance), which, in accordance with Article 438 of the Civil Code of the Russian Federation, means the sending by the Author of his/her materials by way of uploading the same to the online electronic system designed to accept manuscripts for consideration, and subsequently posted in the corresponding section of the Journal’s website on the Internet information and telecommunications network (hereinafter referred to as the Internet).</li> <li>In accordance with the current legislation of the Russian Federation regarding the observance of copyright on electronic information resources, all materials found in a website, including submitted and published in electronic journals, may not be reproduced in whole or in part in any form (electronic or printed) without the prior written permission of the Publisher. Prior permission can be given by publishing an article in the open access with Creative Commons license. The journal requires license users to reference the original source, i.e., the publication, if the Author permits use of the public materials in the context of other documents.</li> </ol> <p> </p> <p><strong>II. Terms used in the Agreement</strong></p> <ol> <li>“Author” refers to an individual (or individuals) whose creative work has led to the creation of the manuscript of a scientific Article, or to a representative of these persons.</li> <li>“Manuscript” is the result of intellectual activity in the form of a scientific work containing text, graphic and numerical data, audiovisual information, program code and other elements submitted by the Author for publication in the Journal; it is also the mean “a draft of an Article submitted by the Author to be published in the Journal”.</li> <li>“Offer” is the current agreement (an offer to the author for the publication of an Article in the Journal).</li> <li>“Publication” is the process of placement of an Article in the Journal.</li> <li>“Article” is the manuscript that has been published in the Journal (after successful selection, editing, type-setting, copyediting, proofreading, translation).</li> <li>“Acceptance of the offer” refers to the full and unconditional acceptance of the offer on the terms specified in paragraph 3 of this agreement (the Author accepts offer by submitting a Manuscript to the Publisher via the online electronic submission system on the Journal’s Internet website).</li> <li>“Journal” is a scientific peer-reviewed periodical registered as a mass media entity in the Roskomnadzor register of the Russian Federation and ISSN-center.</li> <li>“Submission” is an electronic appeal of the Author to the Publisher for the publication of an Article in the Journal by uploading the manuscript and accompanying materials to the online electronic submission system on the Journal’s Internet website).</li> <li>“Publisher” refers to Eco-Vector, which is the Publisher of the journal.</li> <li>Article metadata includes the information that are intended for inclusion in International Scientific Databases and search engines, namely the following: <ul> <li>title of the Article;</li> <li>information about each of the Authors (surname and first name; patronymic; place of work with the postal address indicated, contact information (e-mail));</li> <li>abstract;</li> <li>keywords;</li> <li>thematic rubricator: UDC (Universal Decimal Classification) or other library and bibliographic classification and subject indexes;</li> <li>list of references.</li> </ul> </li> <li>“Editorial board” is the creative team that prepares the journal for publication.</li> <li>“Parties” refers to the Author and the Publisher.</li> <li>“Author Guidelines” are the requirements for Articles published in the Journal, posted in the “For authors” section of the Journal’s Internet website.</li> </ol> <p> </p> <p><strong>III. Subject of the Agreement (Offer)</strong></p> <ol> <li>Under this agreement, the Author grants the Publisher, free of charge for the entire period of validity in accordance with the legislation of the Russian Federation, an exclusive license to use the Article created by the former for publication in the Journal, as well as the rights to use the article in the following ways: <ul> <li>Reproduction of the Article or its sections or parts, as well as the metadata of the Article in any languages, in any material form, including on paper and electronic media, as a separate work in Journals and/or databases (local or in the Internet) of the Publisher and/or other persons, at the discretion of the Publisher;</li> <li>Distribution of the Article or its sections or parts, as well as the metadata of the Article in any languages, on any medium as part of the Journal and/or databases of the Publisher or other persons, at the discretion of the Publisher, or as an independent work around the world whether on Open-Access terms or for a fee without remuneration to the Author;</li> <li>Making the Article or any of its sections or parts, as well as the Article’s metadata in any languages, publicly available in such a way that any person can access the Article from any place, including via the Internet, and at any time of their own choosing;</li> <li>Granting permission/s for the use of the Article or its sections or parts, as well as its metadata in any languages, to third parties with notice to the Author made by posting relevant information on the Journal’s website, without paying remuneration to the Author;</li> <li>Processing the Article (i.e., editing, correcting, annotating, tagging, translating to any languages, typesetting) and using the revised (translated) Article in the aforementioned ways.</li> </ul> </li> <li>Other rights not directly transferred to the Publisher under this Agreement, including patent rights to any process, method etc., described by the Author in the Article, as well as trademark rights, are reserved for the Author.</li> <li>The territory where the rights to the Article are allowed to be used is the whole world.</li> <li>The validity of this Agreement commences only if the manuscript of the Article is accepted for publication in the Journal and only from the moment of sending a notification of acceptance of the Article for publication to the Author from the official e-mail of the Journal.</li> <li>The rights are granted by the Author to the Publisher free of charge; the publication of the Article in the Journal does not entail any financial deductions to the Author.</li> <li>If the Publisher decides to reject the Submission or refuse to publish the Article in the Journal (i.e., retraction of the published Article), this Agreement becomes invalid. The decision to refuse publication will be sent to the Author at the e-mail address specified in the Submission.</li> </ol> <p> </p> <p><strong>IV. Rights and Duties of the Parties</strong></p> <ol> <li>The Author guarantees that: <ul> <li>s/he holds the copyright the exclusive rights to the materials submitted to the Publisher as part of the manuscript of the Article;</li> <li>the rights granted to the Publisher under this agreement have not been previously transferred and will not be transferred to third parties in the future during the duration of the Agreement;</li> <li>the manuscript contains all references to the cited authors and/or publications (materials) provided for under the current copyright legislation;</li> <li>the Author has obtained all the necessary permissions for all information and other materials s/he holds no copyright to and that are used in the manuscript of the Article;</li> <li>the Article manuscript contains only materials permitted to be published in the open press in accordance with the current legislative acts of the Russian Federation, and its publication and distribution will not lead to the disclosure of secret (confidential) information (including state secrets);</li> <li>the Author has informed co-authors about the terms of this Agreement and has received their consent to execute this Agreement under the terms provided for in the Agreement.</li> </ul> </li> <li>The Author carries certain obligations under the terms of the Agreement: <ul> <li>s/he should prepare and submit the manuscript of the Article in accordance with the Author Guidelines posted on the Journal’s website;</li> <li>the Author should not use an electronic copy of the Article for commercial purposes and in other journal publications without the consent of the Publisher;</li> </ul> </li> <li>in the process of preparing a manuscript for publication, the Author is obligated to undertake the following: <ul> <li>make corrections to the text of the manuscript that have been marked by the peer-reviewers and accepted by the editorial board, and/or as necessary, upon the request of the Publisher and the editorial board, finalize the manuscript of the Article;</li> <li>revising and proofreading the manuscript of the Article in accordance with the editorial recommendations;</li> <li>suggest only the minimum of corrections to the type-setted (layout) Article.</li> </ul> </li> <li>The Author has the following rights and duties: <ul> <li>Use preprint or prior-to publication versions of an unpublished Article in the form and content accepted by the Publisher for publication in the Journal. Such prior-to-publish versions can be placed as electronic files on the personal websites of the Author (co-authors) or on the protected external websites of the employers of the Author; however, the Author cannot use the unpublished version(s) for commercial sale or for systematic external distribution by a third party (i.e., post on social media). The author or co-authors must, in turn, carry out certain duties, namely: <ul> <li>include the following warning in the prior-to-publish version: “This is prior-to-publish version of the article accepted for publication in (Journal’s name), © Eco-Vector (year)”;</li> <li>provide the corresponding electronic link to the Publisher’s website at <a href="https://journals.eco-vector.com/">https://journals.eco-vector.com/</a> and/or via the DOI.</li> </ul> </li> <li>Copy or transfer a copy of the published Article in whole or in part to colleagues free of charge for their personal or professional use, for the promotion of academic or scientific research, or for informational purposes of the Author’s employer.</li> <li>Use materials from a published Article in a book written by one of the co-authors.</li> <li>Use figures, tables and text excerpts from the Article for his or her (or co-authors’) own training purposes, or to include them in other published works in printed or electronic format by a third party, or to submit them in electronic format on an internal computer network, or on the public website of the Author (co-authors) or his/her employer.</li> <li>Include the Article in educational collections for use in the classroom, either for free distribution to the Author’s (co-authors’) students or in electronic format on a local server for access by students as part of the training course, as well as for internal training programs at the institution of the Author’s employer.</li> </ul> </li> <li>The Publisher, for its part, is obliged to: <ul> <li>publish the Author’s article in the Journal in printed and electronic form in accordance with the terms of this Agreement;</li> <li>if necessary, as so decided by the Journal’s editorial board, provide the Author with the proofreading of the manuscript and make a reasonable editing;</li> <li>provide to the Author the unlimited access to the final electronic version of the published Article (Version of Record) through the online electronic submission system on the Journal’s Internet website;</li> <li>comply with the Author’s rights as provided for by the current legislation, as well as protect them and take all necessary measures to prevent copyright infringement by third parties.</li> </ul> </li> <li>The Publisher has a right to: <ul> <li>conduct an expert evaluation of the manuscript (peer-reviewing and editorial evaluation) and invite the Author to make the necessary changes (revisions) to the manuscript;</li> <li>provide editing, copyediting, type-setting, proofreading, tagging, indexation and translation of the Article’s manuscript without altering the main content;</li> <li>in any subsequent authorized use by the Author (and/or other persons) of the Journal and/or Article (including any separate part or fragment thereof), require that a link to the Journal, Publisher, Author or other copyright holders, the title of the Article, the Journal’s volume/issue, and the year of publication be specified in the Journal;</li> <li>post preliminary and/or advertising information about the upcoming publication of the Article in the media and other information sources;</li> <li>make changes to the offer in accordance with the procedure established by the offer.</li> </ul> </li> <li>The editorial board of the Journal, headed by the editor-in-chief, has the exclusive rights to select and/or reject materials sent to the Journal editorial office for publications purposes. The manuscript sent by the Author to the Journal editorial office is not subject to return. The editorial board of the Journal does not enter into correspondence about rejection of submissions.</li> <li>In all cases not stipulated and not provided for in this agreement, the parties are obliged to be guided by the relevant current laws of the Russian Federation.</li> </ol> <p> </p> <p><strong>V. Acceptance of the Offer and Execution of the Agreement. Terms of the Agreement</strong></p> <ol> <li>The Author accepts the Offer by submitting the manuscript on the Article to the Publisher through the electronic manuscript submission system on the Journal's Internet website.</li> <li>Acceptance of the offer by the author creates an Agreement in writing (Articles 438 and 1286.1 of the Civil Code of the Russian Federation) on the terms of the offer.</li> <li>This Agreement is valid for the duration of the exclusive rights to the Article.</li> <li>When transferring (alienating) the exclusive right to the Article by the Author to a third party, this Agreement does not terminate.</li> </ol> <p> </p> <p><strong>VI. Procedure for changing and terminating the Agreement</strong></p> <ol> <li>The Publisher has the right to unilaterally change the terms of this Agreement, in advance, at least 10 (ten) calendar days before the entry into force of the intended relevant changes, but with notice to the Author through the Journal’s website or by e-mail to the Author’s e-mail address specified in the Author’s Submission. The changes will take effect from the date specified in the relevant notification.</li> <li>If the Author rejects the changes to the terms of this Agreement, s/he has the right to notify the Publisher by sending a written notification through the online manuscripts submission system, making sure that the same is sent to the official e-mail address of the editorial office.</li> <li>This Agreement may be terminated prematurely, either by agreement of the parties at any time, or on other grounds provided for in this Agreement.</li> <li>The Author has the right to unilaterally withdraw from the execution of this Agreement by sending the Publisher a corresponding notification in writing at least 60 (sixty) calendar days in advance before the expected date of publication of the Article in the Journal.</li> <li>Termination of the Agreement for any reason does not release the parties from liability for any violation of the terms of the Agreement that occurred during the validity period.</li> </ol> <p> </p> <p><strong>VII. Responsibility</strong></p> <ol> <li>The parties are responsible for non-fulfillment or improper fulfillment of their obligations under the Agreement in accordance with the current relevant legislation of the Russian Federation.</li> <li>All information provided by the Author must be reliable. The Author is expected to provide accurate and complete the information to the Publisher. When using false information received from the Author, the Publisher is not responsible for the negative consequences caused by his actions on the basis of the false information provided.</li> <li>With regard to the content of the Article, the Author is solely responsible for compliance with the requirements of the laws of the Russian Federation pertaining to advertising, copyright and related rights’ protection, protection of trademarks and service marks, and the protection of consumer rights.</li> <li>The Publisher does not bear any responsibility under the agreement: <ul> <li>for any actions that are a direct or indirect result of Author’s illegal actions;</li> <li>for any loss incurred by the Author, regardless of whether the Publisher could have foreseen the possibility of such losses or not.</li> </ul> </li> <li>The Publisher is released from liability for violation of the terms of the Agreement if such violation is caused by force majeure, including actions of state authorities (including the adoption of legal acts), fire, flood, earthquake, other natural disasters, lack of electricity and/or computer network failures, strikes, civil unrest, riots, etc.</li> </ol> <p> </p> <p><strong>VIII. Dispute resolution</strong></p> <ol> <li>Disputes and disagreements will be resolved by the parties through negotiations, and in case of failure to reach an Agreement they will strive to seek resolution in accordance with the current legislation of the Russian Federation.</li> <li>If there are unresolved disagreements, the parties agree to resolve the disputes in court at the jurisdiction covered by the Publisher’s location in accordance with the current legislation of the Russian Federation.</li> </ol> <p> </p> <p><strong>IX. Miscellaneous</strong></p> <ol> <li>All notifications, messages, requests, etc. (with the exception of documents that must be sent as originals in accordance with the laws of the Russian Federation) are considered received by the Author if they were transmitted (sent) by the Publisher through the Journal’s website (including by publication), fax, e-mail based on the address specified in the Submission, and other communication channels. The parties recognize the legal force of notifications, messages, requests, etc., transmitted (sent) by the above methods.</li> <li>In the event of claims against the Publisher related to the violation of the exclusive copyright and other intellectual property rights of third parties when creating an article or in connection with the execution of this Agreement by the Author, as well as in connection with the use of the Article by the Publisher in accordance with the Agreement, the author undertakes: <ul> <li>To immediately take measures to resolve disputes with third parties soon after receiving Publisher’s notification, and if necessary, enter into legal proceedings on the Publisher’s side and take all appropriate actions needed to exclude the Publisher from the list of defendants;</li> <li>To reimburse the publisher for the legal costs incurred and expenses and losses caused by the application of measures to secure the claim and execute a court decision, and the money paid to a third party for the violation of exclusive copyright and other intellectual property rights, as well as other losses incurred by the Publisher in connection with the Author’s non-compliance with the guarantees provided by them under this Agreement.</li> </ul> </li> </ol> <p> </p> <p><strong>X. Legal address and details of the Publisher</strong></p> <ul> <li>Eco-Vector</li> <li>Address: 191186, St. Petersburg, Aptekarsky Pereulok, 3 letter A, room 1N</li> <li>TIN: 7806423692; KPP: 784101001; OGRN: 1099847039907.</li> </ul> </details></div>
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Morphological features of the innervation of the rat adrenal gland adipose tissue
https://j-morphology.com/1026-3543/article/view/607423
<p><strong>BACKGROUND</strong><em>:</em> The relevance of studying adipose tissue is due to a lack of understanding of the etiology and pathogenesis of obesity and a lack of research into the endocrine function of adipose tissue. The structure, functions, and innervation characteristics of white and brown adipose tissues of the adrenal gland have received the least attention.</p> <p><strong>AIM</strong><em>: </em>To determine the structure and innervation of rat adrenal adipose tissue using neuroimmunohistochemical markers.</p> <p><strong>MATERIALS AND METHODS</strong><em>: </em>The innervation of the rat adrenal gland’s adipose tissue was examined using immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase, and synaptophysin conducted on paraffin sections (<em>n</em>=10).</p> <p><strong>RESULTS</strong><em>:</em> Unmyelinated nerve fibers and catecholaminergic and cholinergic nerve terminal apparatuses were found in the white and brown adipose tissues of the rat adrenal gland. Parasympathetic and sympathetic postganglionic nerve fibers enter adipose tissue through arterial vessels. Remakov’s varicose axons intensely branch and form passant terminal synaptic networks, which are essential in the innervation of adipocytes in white and brown adipose tissues. Brown and mixed adipose tissues contain the most sympathetic and parasympathetic synaptic structures. Sympathetic fibers are closely connected to the arterial wall and contact brown adipocytes. Varicose axons are found in white adipose tissue, primarily surrounding arterial vessels and rarely between differentiated ring-shaped adipocytes.</p> <p><strong>CONCLUSIONS</strong><em>: </em>The observed differences in sympathetic innervation of white and brown adipose tissues are because brown adipose tissue cells, unlike white adipocytes, perform a secretory function. They impact corticosteroid synthesis by the adrenal gland by producing adipokines. The findings suggest that the sympathetic nervous system controls this process.</p>
Evgenii I. Chumasov
Elena S. Petrova
Dmitriy E. Korzhevskii
Copyright (c) 2024 Eco-Vector
https://creativecommons.org/licenses/by-nc-nd/4.0/
2024-01-22
2024-01-22
161 2
5
13
10.17816/morph.607423
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Morphofunctional characteristics of the pancreas after N-acetylcysteine administration in an acute postradiation pancreatitis model
https://j-morphology.com/1026-3543/article/view/623166
<p><strong>BACKGROUND</strong><em>:</em> The development of effective nondrug and drug-based methods for protecting humans and animals from the effects of ionizing radiation remains important. A morphofunctional assessment of changes in the pancreatic parenchyma is required to determine the degree of radiosensitization of acinar cells and islet cells outside the tumor and during electron treatment of cancer of nearby organs, such as the colon and stomach.</p> <p><strong>AIM</strong><em>: </em>Morphofunctional assessment of the pancreas after N-acetylcysteine administration in a model of acute radiation-induced pancreatitis.</p> <p><strong>MATERIALS AND METHODS</strong><em>: </em>Wistar rats (Rattus Wistar; <em>n</em>=40) were divided into three experimental groups: control group I (<em>n</em>=10); II (<em>n</em>=10) — fractional irradiation with electrons in a total dose of 25 Gy; III (<em>n</em>=10) — administration of N-acetylcysteine before electron irradiation; and IV (<em>n</em>=10) — administration of N-acetylcysteine. A week after the last fraction, animals from all groups were removed from the experiment.</p> <p><strong>RESULTS</strong><em>:</em> A week after electron irradiation, a disruption in histoarchitecture was found in group II due to signs of acute postradiation pancreatitis. Increases in glucose, amylase, and malondialdehyde levels were associated with decreases in insulin and superoxide dismutase levels. In group III, the depth and range of damage to the pancreas were less evident with N-acetylcysteine administration.</p> <p><strong>CONCLUSIONS</strong><em>: </em>After a week of local irradiation with electrons at a total irradiation dose of 25 Gy, the histoarchitecture of the pancreas is disrupted, resulting in acute postradiation pancreatitis. N-acetylcysteine reduces the depth and range of radiation-induced damage while increasing the effectiveness of antioxidant protection.</p>
Grigory A. Demyashkin
Tatyana K. Dubovaya
Dali I. Ugurchieva
Matvey A. Vadyukhin
Pinara S. Akhmedova
Valeria K. Simagina
Copyright (c) 2024 Eco-Vector
https://creativecommons.org/licenses/by-nc-nd/4.0/
2024-01-22
2024-01-22
161 2
15
22
10.17816/morph.623166
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The effects of dark deprivation and chronic alcohol intoxication on the liver of rats
https://j-morphology.com/1026-3543/article/view/623050
<p><strong>BACKGROUND</strong><em>:</em> Nighttime exposure to artificial lighting promotes epiphyseal melatonin deficiency and disrupts the circadian cycle of most body functions in mammals. Several studies have associated these factors with the development of many liver pathologies. A considerable lack of melatonin, along with a mismatch in the daily cycle of vital processes, increases the sensitivity of the liver to alcohol-induced damage and the severity of alcoholic illness.</p> <p><strong>AIM</strong><em>: </em>This study aimed to identify the combined effect of constant lighting and chronic alcohol intoxication (CAI) on the liver structure of both sexes of rats.</p> <p><strong>MATERIALS AND METHODS</strong><em>: </em>TThe study was conducted on 120 male and 80 female outbred Wistar rats aged 6 months. The trial lasted for 3 weeks. Four groups of rats of each sex were formed (control group, CAI group, dark deprivation group, and group exposed to both factors). Preparations stained with hematoxylin and eosin were evaluated. Sudan III staining was used to assess the severity of fatty degeneration, and the expression of <em>Ki-67</em> and <em>p53</em> as markers of proliferation and apoptosis, respectively, was measured immunohistochemically.</p> <p><strong>RESULTS</strong><em>:</em> Chronic alcohol intoxication and dark deprivation cause similar morphological changes in the livers of male and female rats, resulting in fatty degeneration, necrosis, and increased hepatocyte apoptotic activity. The combined effect of these factors causes more dramatic changes in the structure of the liver of males, resulting in the development of cirrhotic changes in 13.3% of them and toxic hepatitis in 20%, whereas only 5% of females show signs of alcoholic hepatitis. Increased <em>Ki-67 </em>expression in male hepatocytes is found only when CAI and dark deprivation are combined. However, in females, an increase in <em>Ki-67</em> expression is observed both alone and when these factors are combined.</p> <p><strong>CONCLUSION</strong><em>: </em>The findings allow us to conclude that female rats adapt more successfully to the independent and combined effects of CAI and dark deprivation than male rats.</p>
David A. Areshidze
Lev V. Kaktursky
Lyudmila M. Mikhaleva
Maria A. Kozlova
Copyright (c) 2024 Eco-Vector
https://creativecommons.org/licenses/by-nc-nd/4.0/
2024-01-22
2024-01-22
161 2
23
35
10.17816/morph.623050
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Tissue science and histology in the system of biomedical scientific and educational disciplines
https://j-morphology.com/1026-3543/article/view/624206
<p>In this article, the authors analyze the role and significance of histology in biomedical scientific and educational disciplines (history, present condition, and controversial issues). This study discusses the formation and development of histology—the science of tissues—and the emergence of notions about tissues and tissue classification. When describing the microscopic structure of plant organs in 1671, the English botanist and physician N. Grew (1641–1712) used the term “tissue” for the first time. In the mid-19th century, German histologists R.A. Kölliker (1817–1905) and F. Leydig (1821–1908) established the present scientific classification of tissues. These authors classified tissues into four main groups: epithelium, connective tissue and blood, nervous tissue, and muscle tissue. Russian scientists A.A. Zavarzin and N.G. Khlopin made significant contributions to developing tissue classification and evolution problems. It is worth noting that the term “tissue,” which was initially interpreted as purely morphological, has gained physiological content; that is, the idea of “tissue” has become a morphofunctional concept. The idea of tissue stability during the ontogenesis stages of organisms is one of the significant paradigms of histology. Fabric variability is allowed within certain limits within the tissue group to which the fabric belongs. There is no compelling evidence of tissue transition from one tissue group to another. The first histology departments appeared in European higher educational institutions in the middle of the 19th century and Russian higher educational institutions in the late 1960s. As a scientific discipline, histology has not exhausted its capabilities; therefore, excluding histology from the nomenclature of scientific specialization is incorrect.</p>
Nikolaj N. Shevlyuk
Alexander A. Stadnikov
Copyright (c) 2024 Eco-Vector
https://eco-vector.com/for_authors.php#07
2024-01-22
2024-01-22
161 2
37
46
10.17816/morph.624206
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Contribution of Vladimir Lazarevich Bykov (1947–2022) to the development of Russian histology, cytology, and embryology
https://j-morphology.com/1026-3543/article/view/624203
<p>The main stages of the life and works of the renowned Russian scientist and teacher Vladimir Lazarevich Bykov are highlighted in this article. His scientific research focused on several fundamental and applied problems in histology, cytology, embryology, and pathomorphology (histophysiology of the thyroid gland, pathomorphology of various organs with candidiasis, morphofunctional characteristics of the oral cavity organs, analysis of the protective mechanisms of the mucous membranes of the digestive organs, history of morphology, and methods of teaching histology, cytology, and embryology). His library of educational literature on histology, cytology, and embryology is a modern encyclopedic body of knowledge on these academic fields. His contributions to the journal Morphology as an editorial board member (1992–2022) and editor-in-chief (2002–2016) are invaluable.</p>
Nikolaj N. Shevlyuk
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2024-01-22
2024-01-22
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10.17816/morph.624203