| Dublin Core |
PKP Metadata Items |
Metadata for this Document |
| 1. |
Title |
Title of document |
MACRO-MICROANATOMIC CHARACTERISTICS OF MESENTERIC LYMPH NODES IN MICE EXPOSED TO THE ACTION OF SOME SPACEFLIGHT FACTORS |
| 2. |
Creator |
Author's name, affiliation, country |
D. B. Nikityuk; Federal Research Centre of Nutrition, Biotechnology and the Food Safety; First I. M. Sechenov Moscow State Medical University |
| 2. |
Creator |
Author's name, affiliation, country |
S. V. Klochkova; First I. M. Sechenov Moscow State Medical University |
| 2. |
Creator |
Author's name, affiliation, country |
N. T. Alekseyeva; N. N. Burdenko Voronezh State Medical University |
| 2. |
Creator |
Author's name, affiliation, country |
A. G. Kvaratskheliya; N. N. Burdenko Voronezh State Medical University |
| 2. |
Creator |
Author's name, affiliation, country |
V. A Tuteliyan; Federal Research Centre of Nutrition, Biotechnology and the Food Safety |
| 3. |
Subject |
Discipline(s) |
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| 3. |
Subject |
Keyword(s) |
mesenteric lymph nodes; lymphoid tissue; gas mixture; factors of space flight |
| 4. |
Description |
Abstract |
Objective - to study the morphological changes of mesenteric lymph nodes after prolonged exposure to a mixture of gases typical for closed spaces in long-term space flighte and at different time intervals after the end of exposure. Material and methods. On micro-microanatomical level, using histological and morphometric methods, the mesenteric lymph nodes were studied in 160 male mice F1 (CBAxC57BL6) subjected to simultaneous inhalation of a mixture of gases (acetone, acetaldehyde and ethanol) during 160 days. Gas concentrations did not exceed maximum permissible values in manned space vehicles. Structural characteristics of lymph nodes were studied at Days 8, 22, 36 and 70 of exposure and at Days 4, 28, 60 and 90 after its termination (the rehabilitation period). Mesenteric lymph nodes were examined in sections stained with hematoxylin - eosin, and using Van Gieson, Mallory and Weigert methods. Results. Mesenteric lymph nodes were characterized by high sensitivity to the action of radiation-chemical factor, which was manifested by a decrease in the absolute number of lymphoid cells and increased proportion of destructively-modified cells (3.2-3.5 times in comparison with those in control group. After Day 60 of a rehabilitation period, the size of the lymphoid nodules and the proportion of lymphoid nodules with the germinal centers was not different from those in the control group. Typical cellular associations were constantly detected. Lymphoid tissue composition was completely restored - the relative numbers of lymphocytes and lymphoblasts was increased and corresponded to that found in a control group, while the number of degeneratively modified cells was reduced. Conclusions. The results showed high sensitivity of the lymph nodes to the action of the gas mixture, however, the structure of lymphoid tissue gradually recovered by Day 60 of a rehabilitation period. |
| 5. |
Publisher |
Organizing agency, location |
Eco-Vector |
| 6. |
Contributor |
Sponsor(s) |
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| 7. |
Date |
(DD-MM-YYYY) |
15.12.2017
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| 8. |
Type |
Status & genre |
Peer-reviewed Article |
| 8. |
Type |
Type |
Research Article |
| 9. |
Format |
File format |
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| 10. |
Identifier |
Uniform Resource Identifier |
https://j-morphology.com/1026-3543/article/view/398187 |
| 10. |
Identifier |
Digital Object Identifier (DOI) |
10.17816/morph.398187 |
| 10. |
Identifier |
Digital Object Identifier (DOI) (PDF (Rus)) |
10.17816/morph.398187-119990 |
| 11. |
Source |
Title; vol., no. (year) |
Morphology; Vol 152, No 6 (2017) |
| 12. |
Language |
English=en |
ru |
| 13. |
Relation |
Supp. Files |
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| 14. |
Coverage |
Geo-spatial location, chronological period, research sample (gender, age, etc.) |
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| 15. |
Rights |
Copyright and permissions |
Copyright (c) 2017 Eco-Vector
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