THE PREORGAN SEPARATION OF THE BLOOD AND ITS ROLE IN THE DEVELOPMENT OF THE FUNCTIONAL HYPEREMIA OF THE MYOCARDIUM

Abstract

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Background. The continued increase of the mortality from the ischemic disease of the heart indicates that it has become the most unreliable organ in human. The situation is aggravated by the fact that until now many questions about the regulation of blood-lymph circulation in the intact heart remain either controversial or unresolved. First of all, this concerns the mechanism of development of functional (working) hyperemia of the myocardium. Aim. The purpose of this study is the morphological and functional substantiation of the concept about the significance of pre-organ blood separation in the mechanism of development of functional myocardial hyperemia. Material and Methods. The investigation was performed on inbred seven cats and inbred five dogs in full accordance with Russian and International ethical principles. The blood and lymph channel of the heart was studied by the intravascular methods of Grant and Ranier-Goyer in the supravital conditions. The movement of the ultrafiltrate of blood plasma in the interstitial space and its resorption in the lymphatic vessels was studied by using the vitally coloring dyes (1% solution of the hematoxylin and 0.25% solution of the silver nitrate), which to allow to reveal of the local features of the vascular permeability. Results and Discussion. The morphological and functional data obtained in this study may serve as the grounding for a new conception about the role of the pre-organ separation of the blood in the development of functional hyperemia of the myocardium.