TWO TYPES OF THE COLLAGEN MEMBRANES FOR THE PLASTIC RESTORATION OF ARTICULAR CARTILAGE DEFECTS IN THE EXPERIMENT



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Background. Articular cartilage injuries are common in the field of orthopedics. Cartilage has a poor regenerative capacity. Accordingly, trauma-associated cartilage defects are often treated surgically by covering with synthetic collagen membranes. Aim. To compare the regenerative capacities of two types of synthetic collagen membranes utilized in a rat model of full thickness defect. Material and Methods. Full thickness cartilage defects were made surgically in patellofemoral grove and covered with one of the two collagen membranes: Chondro-Gide® (Switzerland) or Chondrotek (Russia). Control group was left without coverage. The International Cartilage Repair Society (ICRS) score and histological analysis were carried out in 2 and 4 months after implantation. Results and Discussion. Both collagen membranes have a positive effect on cartilage repair since the thickness of newly formed tissue was significantly higher than in control group. Formation of fibrocartilage was observed in all groups. No significant difference was observed between two membranes repair capacity. Conclusions. Both collagen membranes have comparable repair capacity and both failed to facilitate formation of hyaline cartilage.
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© Afanasyevskaya E.V., Medvedeva E.V., Gazimieva B.M., Kurenkova A.D., Kytko O.V., Panyushkin P.V., Istranov L.P., Istranova E.V., Shekhter A.B., Lichagin A.V., Chagin A.S., Telpukhov V.I., 2018

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