LIVER REGENERATION

Аннотация

Полный текст

Background. Liver transplantation remains the only option for treating liver failure but is only available for a small number of patients. Alternative methods of treatment can expand the number of patients receiving effective treatment. Aim. To study the features of the process of liver regeneration. Material and Methods. The articles for the period from 2012 to 2017 were analyzed. The search was performed in the databases PubMed, Embase, Scopus. The words used are «liver regeneration», «stem cell-derived hepatocytes», «and engineered liver». Results and Discussion. Tumor necrosis factor (TNFα), interleukin-6 (IL-6), hepatocyte growth factor (HGF) cause hepatocytes to pass from G0 to the S-phase of the cell cycle. Chronic liver damage causes a canal reaction in which liver progenitor cells (LPC) participate. Normally LPC show the ability of bipotential differentiation to both hepatocytes and cholangiocytes. Cell therapy by repopulation with transplanted hepatocytes is a safe and effective method, but only leads to a short-term partial correction of metabolic disorders, it is necessary to optimize engraftment and spreading. Liver diseases at the final stage are incompatible with cellular therapy due to the lack of a suitable environment for cell engraftment and repopulation. It is important to prove that the bioengineering liver is clinically safe, the network of the vasculature is not damaged to provide functional vascularization. Conclusions. Replication of hepatocytes is de pendent on the effect of growth factors and cytokines - TGF-α, HGF and IL-6, LPC can differentiate to both hepatocytes and cholangiocytes, the best solution is the use of induced pluripotent stem cells.