HISTOLOGICAL EFFECTS OF CHRONIC CONSUMPTION OF AQUEOUS COLA NITIDA EXTRACT ON LATERAL GENICULATE BODY OF ADULT ALBINO WISTAR RATS

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Aim. Cola nitida is a well documented natural stimulant with abundance of caffeine which excites the central nervous system. The purpose of this study is to assess the histological effects of aqueous cola nitida extract on the lateral geniculate nucleus of adult albino wistar rats. A total of 16 male Albino wistar rats, weighing 97 g to 160 g were used. Material and Methods. Sixteen adult male wistar rats were divided into four groups of four animals each. Treated groups were orally administered with 300, 400 and 500 mg/kg body weight of aqueous Cola nitida extract. Control group was given distilled water. All the animals were fed with rat chow and water liberally for 28 days. The rats were weighed on the first and final days of drug administration with an electronic weighing balance. The rats were sacrificed by chloroform inhalation. The brains were dissected out, weighed immediately and transferred into a bouins fluid for histological study. Results and Discussion. The result showed significant (p<0.05) weight gain in all the groups. Histology of the lateral geniculate body of rats treated with Cola nitida extract revealed liquifactive necrosis, cellular degeneration, hypertrophy and vacuolations. Conclusions. We conclude that prolong consumption of Cola nitida is toxic to the cells of the lateral geniculate body as compared with the control.