DESCRIPTION OF THE STIMULATED PLEURAL ADHESION FORMATION

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Aim. To describe the stimulated pleural adhesion formation Material and Methods. 270 nonlinear rats (males) were modeled by the pleural empyema, followed by the Platelet-Rich Plasma Therapy (PRP Therapy). For this purpose, 1 ml of plasma enriched with platelets was injected into the pleural cavity. The rats were sacrificed on the 30th day after the injection. Results and Discussion. All rats of the pleural empyema model showed the residual pleural cavities of different size filled with the purulent content. Microscopically, the residual cavities showed the diffuse leukocyte infiltration, focal destruction of mesothelium, and an accumulation of tissue detritus before PRP Therapy. With PRP Therapy, a total obliteration of empyema cavities was detected in 41 (30.4%) of the experimental animals. By the 30th day after plasma injection, the residual cavities were almost completely filled with the collagen fibers with a low number of lymphocytes and capillaries in the formed adhesions. Conclusions. Stimulation of the pleural adhesion formation by the pleural injection of plasma enriched with platelets is an effective therapy based on the local development of multiple adhesions which fill the residual cavity. An additional advantage is a safety of the biological substrate used in this method of treatment.