PECULIARITIES OF TATTOO PIGMENT DISTRIBUTION IN THE SKIN

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Aim. To describe the features of tattoo pigment distribution in the skin. Material and Methods. An experimental study was carried out on 30 nonlinear white rats (males) who were tattooed with black ink. The animals were sacrificed on 10th day. The skin was sampled, processed, and stained with hematoxylin and eosin according to the standard protocol for the pathohistological examination. Material and Methods. In the early stages after tattooing, the accumulation of the pigment was observed in the superficial layers of derma, particularly in the perivascular area of the papillary layer. The pigment was distributed in a various pattern, from the relatively large well-distinguishable granules directly under the epidermis to the «dust-like» infiltration of the papillary dermis. Loose connective tissue of papillary layer showed the features of edema with uneven filling of the blood vessels. The margination of leukocytes in the blood vessels was observed. The degree of the epidermis adherence to the papillary layer of dermis varied, and it depended on the severity of the skin edema. In some skin areas there were the clefts between the basal layer of epidermis and the papillary layer of dermis. In the reticular layer of dermis, the foci of leukocyte infiltration mainly of neutrophils with few eosinophils and lymphocytes were identified. Conclusions. The described pattern of pigment distribution within the tattooed skin showed the irregular distribution of ink and a pronounced inflammatory reaction to the injected pigment in the early tattoos.