MORPHOLOGICAL CHANGES AFTER PLASTIC RECONSTRUCTION OF THE PLEURAL CAVITY IN THE EXPERIMENT

详细

全文:

Aim. The aim of the study is early prevention of a postpneumonectomy syndrome in experiment. Material and Methods. During the first series of the experiment the left pneumonectomy was conducted in 5 chinchilla rabbits. In the second series of experiments the plastic reconstruction of 1/3 volume of postpneumonectomy cavity was made in 5 animals. During the third series of experiments the plastic reconstruction of 2/3 volume of postpneumonectomy cavity in 5 rabbits was executed. In the postoperative period CT-scan control was carried out at 30, 90, 180 days. The animals were euthanized on 180 day. Lungs were studied using microscopic sections and histotopograms stained with hematoxylin-eosine and picrofuksin. Results and Discussion. In the postoperative period after the left pneumonectomy at the level of Th6 the right lung was twice enlarged in a lateral size (30.6±4.7 mm on average), the area of the lung was 1.5 times enlarged from 1141±132 to 1756±167 mm2. After the plastic reconstruction the area of the lung is enlarged 1.3 and 1.2 times. Histotopograms showed the enlargement of lung airness with a large number of hyperinflated air-cell. Microscopic sections showed that acini had flattened shape, some acini had the destroyed wall and were merged in microcavities of 500-1500 microns in size. In case of plastic reconstruction of the cavity after the removal of the lung mediastinum organs and structures are not displaced, the lung is stretched moderately. On histotopograms the lung structure differs slightly from the norm, microcavities of 150-250 microns in size are located evenly in the central and peripheral parts of the lung. Difference between the second and third experimental series is the high enlargement of a heart segment of the right lung in case of the plastic reconstruction of 1/3 volume of postpneumonectomy cavity. Histological sections showed enlarged acinuses, destruction of acinus’s wall is occasional.