EFFECT OF İLOPROST ON FUNCTIONAL RECOVERY AFTER CRUSH İNJURY OF THE SCIATIC NERVE

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Background. Vascular damage of the sciatic nerve results to subperineurial degeneration/demyelination injury. Aim. In the present study, it was aimed to study the effect of iloprost on recovery of the sciatic nerve after crush injury. Material and Methods. A total number of 40 Wistar rats were used for this purpose and divided into four groups [Group 1: Control, Group 2: Sham, Group 3: Crush injury+iloprost (-), Group 4: Crush injury+iloprost (+)]. Results and Discussion. Sciatic nerve regeneration was evaluated by walking track analysis, pinch test, light and electron microscopy and antioxidant effect of iloprost was evaluated by biochemical analysis. Conclusions. Sciatic function test, pinch test, electrophysiologic, and biochemical analyses revealed that the iloprost showed a beneficial effect on recovery of function after crush injury.