Morphological changes in fetal part of allantoic placenta in rats exposed to acute hypoxia
- 作者: KHOZHAI LI1, SHISHKO TT1, KOSTKIN VB1, OTELLIN VA1
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隶属关系:
- RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of Physiology
- 期: 卷 132, 编号 6 (2007)
- 页面: 61-64
- 栏目: Articles
- ##submission.dateSubmitted##: 09.05.2023
- ##submission.datePublished##: 15.12.2007
- URL: https://j-morphology.com/1026-3543/article/view/399047
- DOI: https://doi.org/10.17816/morph.399047
- ID: 399047
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oxygen concentration in the gas mixture) for 1 hr. Placenta was studied 1 and 3 days later. Short-term acute hypoxia during pregnancy was shown to induce an impairment of formation and maturation of the fetal part of placenta. In the labyrinth zone, apoptosis was enhanced and a significant number of hyperchro-matic nuclei appeared in cyto- and syncytiotrophoblast, which lead to the loss of some cells of cytotrophoblast and resulted in the retardation of its development and transformation into syncytiotrophoblast. One day following hypoxia, a stimulation of adaptive processes was evident as demonstrated by a dramatic rise of mitotic activity in the cytotrophoblast of the labyrinth zone of placental fetal part. However, a delay of the labyrinth zone development persisted till the end of pregnancy. Number and volume of fetal blood vessels were decreased as compared to those in control. A sharp decline of number and size of sinusoids containing maternal blood as well as a significant decrease of blood volume in the sinusoids, suggest a spasm of the uterine and placental vessels causing an impairment of utero-placental blood circulation and development of placental insufficiency
作者简介
L KHOZHAI
RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of PhysiologyОтдел морфологии; лабо-ратория онтогенеза нервной системы; Институт экспериментальной медицины РАМН, Институт физиологии им. И.П. Павлова РАН; RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of Physiology
T SHISHKO
RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of PhysiologyОтдел морфологии; лабо-ратория онтогенеза нервной системы; Институт экспериментальной медицины РАМН, Институт физиологии им. И.П. Павлова РАН; RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of Physiology
V KOSTKIN
RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of PhysiologyОтдел морфологии; лабо-ратория онтогенеза нервной системы; Институт экспериментальной медицины РАМН, Институт физиологии им. И.П. Павлова РАН; RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of Physiology
V OTELLIN
RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of PhysiologyОтдел морфологии; лабо-ратория онтогенеза нервной системы; Институт экспериментальной медицины РАМН, Институт физиологии им. И.П. Павлова РАН; RAMS Scientific Research Institute of Experimental Medicine, RAS I.P. Pavlov Institute of Physiology
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