电邮这篇文章 THE NUCLEOLUS OF THE CELL IS THE SITE OF IRON ACCUMULATION IN THE SUBSTANTIA NIGRA NEURONS OF THE HUMAN BRAIN
- 作者: Sukhorukova Y.G.1, Grigoriev I.P.1, Kolos Y.A.1, Korzhevskiy D.E.1
-
隶属关系:
- RAMS North-Western Branch Institute of Experimental Medicine
- 期: 卷 142, 编号 6 (2012)
- 页面: 061-062
- 栏目: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399622
- DOI: https://doi.org/10.17816/morph.399622
- ID: 399622
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
Distribution of iron in the substantia nigra of the human brain (10 men and women aged 27–78 years) was studied using Perls’ histochemical method. Iron ions were demonstrated in the nigral neuropil and melanin-containing neurons. For the first time the nuclei of some neurons were found to contain iron accumulations. The intranuclear iron inclusions correspond to the nucleolus according to their sharp outline and sizes. Detection of iron in the neuronal nucleolus may contribute to the understanding of mechanisms of iron neurotoxicity for nigral dopaminergic neurons.
关键词
全文:
作者简介
Ye. Sukhorukova
RAMS North-Western Branch Institute of Experimental Medicine
Email: len48@inbox.ru
I. Grigoriev
RAMS North-Western Branch Institute of Experimental Medicine
Email: ipg-iem@yandex.ru
Ye. Kolos
RAMS North-Western Branch Institute of Experimental Medicine
Email: iemmorphol@yandex.ru
D. Korzhevskiy
RAMS North-Western Branch Institute of Experimental Medicine
Email: dek2@yandex.ru
参考
- Коржевский Д. Э., Григорьев И. П. и Отеллин В. А. Применение обезвоживающих фиксаторов, содержащих соли цинка, в нейрогистологических исследованиях. Морфология, 2006, т. 129, вып. 1, с. 85–86.
- Оксова Е. Е. О вакуолизации ядрышка нейронов коры головного мозга человека. Арх. анат., 1972, т. 63, вып. 10, с. 33–36.
- Alkhateeb A. A. and Connor J. R. Nuclear ferritin: a new role for ferritin in cell biology. Biochim. Biophys. Acta, 2010, v. 1800, № 8, p. 793–797.
- Meguro R., Asano Y., Odagiri S. et al. Nonheme-iron histochemistry for light and electron microscopy: a historical, theoretical and technical review. Arch. Histol. Cytol., 2007, v. 70, № 1, p. 1–19
- Roschzttardtz H., Grillet L., Isaure M.-P. et al. Plant cell nucleolus as a hot spot for iron. J. Biol. Chem., 2011, v. 286, № 32, p. 27863–27866.
- Wypijewska A., Galazka-Friedman J., Bauminger E. R. et al. Iron and reactive oxygen species activity in parkinsonian substantia nigra. Parkinsonism Relat. Disord., 2010, v. 16, № 5, p. 329–333.
补充文件
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).