MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL PECULIARITIES OF PLACENTAL TERMINAL VILLI IN A PHYSIOLOGICAL AND GESTOSIS-COMPLICATED PREGNANCY AND IN PREGNANCY IN PATIENTS WITH TYPE I DIABETES AND GESTOSIS

Using the methods of light microscopy and immunohistochemistry, the structural organization of terminal placental villi was studied in a physiological and gestosis-complicated pregnancy, as well as in women with type I diabetes mellitus and gestosis. The studies have revealed both morphological and immunohistochemical differences in the ratio of structural components in the terminal placental villi, including decreased diameter of the villi, increased degree of capillarization, reduced proportion of the connective tissue, increased type I, II, III, and VI collagen content in the connective tissue extracellular matrix and the decreased type IV collagen content in basement membranes in gestosis-complicated pregnancy. These changes were more expressed in the combination of gestosis and type I diabetes mellitus. It was found that the compensatory processes in gestosis are predominantly provided by syncytiotrophoblast, while in type I diabetes mellitus they were due to the increased capillarization of the terminal villi.

placenta, terminal villi, immunohistochemistry, gestosis, diabetes mellitus