MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL PECULIARITIES OF PLACENTAL TERMINAL VILLI IN A PHYSIOLOGICAL AND GESTOSIS-COMPLICATED PREGNANCY AND IN PREGNANCY IN PATIENTS WITH TYPE I DIABETES AND GESTOSIS



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Using the methods of light microscopy and immunohistochemistry, the structural organization of terminal placental villi was studied in a physiological and gestosis-complicated pregnancy, as well as in women with type I diabetes mellitus and gestosis. The studies have revealed both morphological and immunohistochemical differences in the ratio of structural components in the terminal placental villi, including decreased diameter of the villi, increased degree of capillarization, reduced proportion of the connective tissue, increased type I, II, III, and VI collagen content in the connective tissue extracellular matrix and the decreased type IV collagen content in basement membranes in gestosis-complicated pregnancy. These changes were more expressed in the combination of gestosis and type I diabetes mellitus. It was found that the compensatory processes in gestosis are predominantly provided by syncytiotrophoblast, while in type I diabetes mellitus they were due to the increased capillarization of the terminal villi.

About the authors

T V SAZHINA

Department of Histology, Embryology and Cytology and Department of Pathological Anatomy, Novosibirsk State Medical University

Department of Histology, Embryology and Cytology and Department of Pathological Anatomy, Novosibirsk State Medical University

Yu I SKLYANOV

Department of Histology, Embryology and Cytology and Department of Pathological Anatomy, Novosibirsk State Medical University

Department of Histology, Embryology and Cytology and Department of Pathological Anatomy, Novosibirsk State Medical University

T A AGEYEVA

Department of Histology, Embryology and Cytology and Department of Pathological Anatomy, Novosibirsk State Medical University

Department of Histology, Embryology and Cytology and Department of Pathological Anatomy, Novosibirsk State Medical University

References

  1. Автандилов Г.Г. Медицинская морфометрия. М., Медицина, 1990.
  2. Аксенов А.Н., Бодяжина В.И., Ванина Л.В. и др. Физиологическая и патологическая беременность, фетоплацентарная система. В кн.: Справочник по акушерству и гинекологии. М., Медицина, 1996.
  3. Балаболкин М.И. Диабетология. М., Медицина, 2000.
  4. Гланц С. Медико-биологическая статистика. М., Практика, 1999.
  5. Дедов И.И. и Шестакова М.В. Сахарный диабет: ретинопатия, нефропатия. М., Медицина, 2001.
  6. Коржевский Д.Э., Отеллин В.А., Неокесарийский А.А. и др. Организация и цитохимические особенности барьерных структур плаценты человека. Морфология, 2006, т. 129, вып. 3, с. 63-64.
  7. Милованов А.П. Патология системы мать-плацента-плод. М., Медицина, 1999.
  8. Савельева Г.М. Плацентарная недостаточность. М., Медицина, 1991.
  9. Стрижаков А.Н., Игнатко И.В. и Ковалева Л.Г. Становление и развитие внутриплацентарного кровообращения при физиологической беременности. Акуш. и гин., 1996, № 2, с. 16-21.
  10. Шехтман М.М. Руководство по экстрагенитальной патологии у беременных. М., Триада-Х, 2003.
  11. Юрина Н.А. и Радостина А.И. Морфофункциональная гетерогенность и взаимодействие клеток соединительной ткани. М., Изд-во Ун-та дружбы народов, 1990.
  12. Barton G.J. and Tham S.W. Formation of vasculo-syncitial membranes in human placenta. J. Dev. Physiol., 1992, v. 18, № 1, p. 43-47.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies