Gas composition of alveolar air and tolerability of personal respiratory protection equipment

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Abstract

Introduction. When using personal protective equipment for respiratory organs of an insulating type in case of depletion of a regenerative cartridge, hypoxic-hypercapnic changes in the gas composition of the body occur, which have a negative effect on the tolerance of personal protective equipment for respiratory organs. The combination of additional respiratory resistance with hypoxia and hypercapnia further worsens the tolerance of respiratory protective equipment. The purpose of this study was to study the tolerance of personal respiratory protection when changing the gas composition of the alveolar air.

Material and methods. The study was conducted on healthy subjects of both sexes (78 people), aged 20 to 36 years. To simulate the conditions for the use of personal respiratory protective equipment, inspiratory resistive respiratory loads of 20% of the maximum intraoral pressure were used during the Mueller test. The tolerance of respiratory protective equipment was evaluated using the Borg visual analog scale of dyspnea, which reflected the level of subjective discomfort occurring due to additional respiratory resistance is turned on. The methodology for changing the gas composition of the alveolar air in the subjects consisted of using a system that allowed adding oxygen from the line to the closed spirograph circuit and turning the carbon dioxide adsorber on and off.

Results. The tolerance of personal respiratory protection is associated with the nature of the gas composition of the alveolar air. A minimum of subjective discomfort was observed in the presence of hyperoxic-hypocapnic composition of the pulmonary air; on the contrary, an increase in subjective discomfort on the Borg scale was observed with a reduced oxygen content and an increased concentration of carbon dioxide. The use of personal respiratory protective equipment against the background of hypoxia-hypercapnia negatively changes the functional state of the body: there was observed an increase in physiological expenditures by leading effectors. Normalization of the gas composition of the body under the use of personal respiratory protection did not lead to complete optimization of the functional state of the subjects.

Conclusion. Hypoxia and hypercapnia arising from the depletion of regenerative cartridges of the respiratory protective equipment of an insulating type leads to a significant deterioration in the tolerance to additional respiratory resistance. The alleged mechanism of this phenomenon should be considered as an increase in fatigue of the respiratory muscles.

About the authors

Yury Yu. Byalovsky

Ryazan State Medical University

Author for correspondence.
Email: b_uu@mail.ru
ORCID iD: 0000-0002-6769-8277

MD, Ph.D., DSCi., Head of the Department of Pathophysiology of the Ryazan State Medical University, Ryazan, 390026, Russian Federation.

e-mail: b_uu@mail.ru

Russian Federation

V. A. Kiryushin

Ryazan State Medical University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1258-9807
Russian Federation

N. I. Prokhorov

I.M. Sechenov First Moscow State Medical University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4510-2890
Russian Federation

I. S. Rakitina

Ryazan State Medical University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9406-1765
Russian Federation

N. V. Chudinin

Ryazan State Medical University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2441-9522
Russian Federation

References

  1. Chashchin V.P., Nikanov A.N., Anfalova G.L. Analysis of the effectiveness of personal respiratory protection from dust in mica processing plants. Ekologiya cheloveka [Human Ecology]. 2006; 4: 55–8. (in Russian)
  2. Kaptsov V.A., Chirkin A.V. On the effectiveness of respiratory protective equipment as a means of preventing disease (review). Toksikologicheskiy vestnik [Toxicological Bulletin]. 2018; 2: 2–4. (in Russian)
  3. Chudinin N.V., Kiryushin V.A., Rakitina I.S. Assessment of occupational risk as a method for predicting the health status of workers employed in hazardous working conditions. Nauka molodykh – Eruditio Juvenium [Science of the Young – Eruditio Juvenium]. 2013; 1: 5–7. (in Russian)
  4. Malashenko A.V. The multifactorial genesis of occupational pulmonary pathology in miners of uranium mines. Meditsinskaya radiologiya [Medical Radiology]. 2010; 2: 5–8. (in Russian)
  5. Golinko V.I., Naumov M.M., Cheberyachko S.I., Radchuk D.I. Up to date one-time effectiveness of one-time disposable prototypical respirators for European standards. Metallurgicheskaya i gornorudnaya promyshlennost’ [Metallurgical and Mining Industry]. 2011; 5: 118–21. (in Russian)
  6. Sorokin Yu.G. New in personal protective equipment. Bezopasnost’ zhiznedeyatel’nosti [Life Safety]. 2006; 1: 11–7. (in Russian)
  7. Romanov V.V., Rubtsov V.I., Klochkov V.N., Surovtsev N.A., Timoshenko A.I. State sanitary and epidemiological surveillance of personal protective equipment for respiratory organs at radiation hazardous facilities. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2006; 4: 78–81. (in Russian)
  8. Petryanov I.V., Koscheev V.S., Basmanov P.I. et al. Light respirators. 2nd ed [Logkiye respiratory. 2 izd.]. Moscow: Science; 2015. (in Russian)
  9. Byalovsky Yu.Yu., Bulatetskiy S.V., Kiryushin V.A., Prokhorov N.I. Human immunological parameters in the conditions of application of individual respiratory protective equipment. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. н2017; 96 (8): 717–20. (in Russian)
  10. Kirillov V.F. et al. On personal protective equipment for respiratory organs of workers. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2013; 4: 25–6. (in Russian)
  11. Alexandrova N.P. The mechanisms of compensatory reactions of the respiratory system to inspiratory resistive loads. Autoabstract of Diss. St. Petersburg; 2003. (in Russian)
  12. Byalovsky Yu.Yu., Abrosimov V.N. Pneumatic dispenser for external breathing resistance. Description of the invention to the patent of the Russian Federation No. 2071790; 1997. (in Russian)
  13. Shatalov E.V., Shcherbakov M.G., Baldych A.A., Drozdov S.N. Medical and technical aspects of the operation of personal protective equipment of a military man. Voyennaya mysl’ [Military thought]. 2008; 4: 40–5. (in Russian)
  14. Mironov L.A. The use of personal protective equipment [Primeneniye sredstv individual›noy zashchity]. Nizhniy Novgorod: Biota-plus; 2009. (in Russian)
  15. Borg G. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982; 14 (5): 377–5.
  16. Byalovsky Yu.Yu., Bulatetskiy S.V. Physiological mechanisms person’s resistive breathing [Fiziologicheskiye mekhanizmy rezistivnogo dykhaniya cheloveka]. Voronezh: RITM Publishing House; 2018. (in Russian)
  17. Byalovsky Yu.Yu. Reciprocal reactions of the body to different values of increased respiratory resistance. Rossiyskiy mediko-biologicheskiy vestnik imeni akademika I.P. Pavlova [Russian Medical and Biological Bulletin of Academician I.P. Pavlov]. 2016; 1: 19–25. (in Russian)
  18. Fahey P.J., Hyde R.W. Detection of depressed ventilatory drive in patients with obstructive pulmonary diseases. Chest. 1983; 84 (1): 19–26.
  19. Belov A.F., Byalovsky Yu.Yu., Lapkin M.M. Information and diagnostic system for psychophysiological studies of man. Ryazan; 1990. (in Russian)
  20. Suslina I.V. Improving the functional state of the respiratory muscles of athletes as a result of training with additional inelastic resistance to breathing. Fizicheskoye vospitaniye i sportivnaya trenirovka [Physical Education and Sports Training]. 2016; 2 (16): 63–5. (in Russian)
  21. Gorbanyova E.P., Kamchatnikov A.G., Solopov I.N., Segizbaeva M.O., Alexandrova N.P. Optimization of respiratory function through training with additional resistive resistance. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova [Russian physiological journal of I.M. Sechenov]. 2011; 97 (1): 83–8. (in Russian)
  22. Europäische Norm DIN EN 529: 2006 Atemschutzgeräte – Empfehlungen für Auswahl, Einsatz, Pflege und Instandhaltung – Leitfaden. Brüssel: CEN; 2006.
  23. Kaptsov V.A., Chirkin A.V. On the assessment of the effectiveness of personal respiratory protection. Bezopasnost’ v tekhnosfere [Safety in Technosphere]. 2015; 4: 5: 7–8. (in Russian)
  24. Vedyasova O.A., Eskov M.V., Filatova O.E. Systematic compartmental-cluster analysis of the mechanisms of resistance of the respiratory rhythm of mammals [Sistemnyy kompartmentno-klasternyy analiz mekhanizmov ustoychivosti dykhatel›noy ritmiki mlekopitayushchikh]. Samara: Ofort; 2005. (in Russian)
  25. Merkulova N.A., Inyushkin A.N., Belyakov V.I. The respiratory center and the regulation of its activity suprabulbar structures [Dykhatel›nyy tsentr i regulyatsiya yego deyatel›nosti suprabul›barnymi strukturami]. Samara: Samara University Press; 2007. (in Russian)
  26. Safonov V.A., Tarasova H.A. Structural and functional organization of the respiratory center. Fiziologiya cheloveka [Human physiology]. 2006; 1: 118–31. (in Russian)
  27. Safonov V.A., Minyaev V.I., Polunin I.N. Breath [Dykhaniye]. Moscow; 2000. (in Russian)
  28. Segizbaeva M.O., Alexandrova N.P. The use of the stress-time index to assess the functional state of inspiratory muscles. Ul’yanovskiy mediko-biologicheskiy zhurnal [Ulyanovsk Medical Biological Journal]. 2014; 2: 78–7. (in Russian)
  29. Chereshnev V.A., Byalovsky Y.Yu., Bulatetskiy S.V., Davydov V.V. Immunological indicators of a person under conditions of increased resistance to breathing. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki [Bulletin of the Ural Medical Academic Science]. 2018; 15 (4): 555–8. (in Russian)
  30. Segizbaeva M.O., Alexandrova N.P. Assessment of the resistance of different groups of inspiratory muscles to fatigue during physical exertion against the background of a simulated airway obstruction. Fiziologiya cheloveka [Human Physiology]. 2014; 40 (6): 114–22. (in Russian)
  31. Fehrenbach H., Wagner C., Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017; 367: 551–69.
  32. Israel E., Reddel H.K. Severe and Difficult-to-Treat Asthma in Adults. N Engl J Med. 2017; 377: 965–76.
  33. Shrine N., Portelli M.A., John C. Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. Lancet Respir Med. 2019; 7: 20–34.

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