Morphological changes in parenchymal organs of laboratory animals in acute effect of carbon tetrachloride

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Abstract

Introduction. Among noninfectious diseases, one of the leading places belongs to pathologies caused by the action of industrial toxicants. In this regard, the search for drugs for the prevention and treatment of various intoxications is one of the priority tasks of public health. Treatment of intoxication with drugs with antioxidant and antihypoxic activity is more effective.

The aim of this study was to investigate morphological changes in parenchymal organs (liver, kidneys, and pancreas) under acute exposure to high doses of carbon tetrachloride and to evaluate the effectiveness of their correction with a new composition of oxymethyluracil with ascorbic acid.

Material and methods. The composition of 5-hydroxy-6-methyluracil with ascorbic acid was first synthesized at the Ufa Institute of Chemistry, Ufa Federal Research Center, RAS. The preventive effect of the new drug was studied in comparison with “Heptor” on the carbon tetrachloride-induced liver injury model. Morphological studies of the liver, pancreas, and kidneys of laboratory animals were carried out.

Results. Studies have shown the prophylactic administration of new composition of 5-hydroxy-6-methyluracil with ascorbic acid to have a protective effect on the structure of parenchymal organs in acute carbon tetrachloride intoxication, comparable to the drug “Heptor” (possibly superior). However, reparative properties were observed only in the drug “Heptor”.

Conclusion. Comparative estimation of morphological changes in parenchymal organs under acute exposure to high doses of carbon tetrachloride indicates the protective effect of prophylactic administration of the composition of 5-hydroxy-6-methyluracil with ascorbic acid, comparable to the drug “Heptor” (possibly superior).

About the authors

Elvira F. Repina

Ufa research institute of occupational health and human ecology

Author for correspondence.
Email: e.f.repina@bk.ru
ORCID iD: 0000-0001-8798-0846

MD, Ph.D., senior researcher of the department of toxicology and genetics with an experimental clinic of laboratory animals Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russia.

e-mail: e.f.repina@bk.ru

Russian Federation

Denis O. Karimov

Ufa research institute of occupational health and human ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0039-6757
Russian Federation

Samat S. Baygildin

Ufa research institute of occupational health and human ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1856-3173
Russian Federation

Gulnara V. Timasheva

Ufa research institute of occupational health and human ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0003-2435-6936
Russian Federation

Nadezhda Yu. Khusnutdinova

Ufa research institute of occupational health and human ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0001-5596-8180
Russian Federation

Alfiya R. Gimadieva

Ufa Institute of Chemistry Ufa Federal Research Center of RAS

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2995-310X
Russian Federation

Lyalya A. Musina

All-Russian Center for Eye and Plastic Surgery

Email: noemail@neicon.ru
ORCID iD: 0000-0003-1237-9284
Russian Federation

Denis A. Smolyankin

Ufa research institute of occupational health and human ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-7957-2399
Russian Federation

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Copyright (c) 2024 Repina E.F., Karimov D.O., Baygildin S.S., Timasheva G.V., Khusnutdinova N.Y., Gimadieva A.R., Musina L.A., Smolyankin D.A.


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