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Three-component synthesis and antibacterial activity of 5-Aryl-4-acyl-3-hydroxy-1-(4-methoxyphenyl)-3-pyrroline-2-ones
- Authors: Kasimova N.N.1, Maiamsina O.O.1,2, Dubrovina S.S.1, Gein V.L.1
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Affiliations:
- Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
- Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation
- Issue: Vol 95, No 5-6 (2025)
- Pages: 191-198
- Section: Articles
- URL: https://j-morphology.com/0044-460X/article/view/688760
- DOI: https://doi.org/10.31857/S0044460X25050034
- EDN: https://elibrary.ru/FISLVD
- ID: 688760
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Abstract
A series of new 5-aryl-4-acyl-3-hydroxy-1-(4-methoxyphenyl)-3-pyrrolin-2-ones was synthesized by the reacting of methyl esters of aroylpyruvic acids with a mixture of aromatic aldehyde and p-anisidine. Antibacterial activity of the obtained compounds was studied in vitro against Staphylococcus aureus and Escherichia coli strains.
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About the authors
N. N. Kasimova
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: pufmail135@gmail.com
ORCID iD: 0009-0001-6348-7333
Russian Federation, Perm, 614990
O. O. Maiamsina
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation
Email: pufmail135@gmail.com
Russian Federation, Perm, 614990; Perm, 614990
S. S. Dubrovina
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Email: pufmail135@gmail.com
Russian Federation, Perm, 614990
V. L. Gein
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Email: pufmail135@gmail.com
ORCID iD: 0000-0002-8512-0399
Russian Federation, Perm, 614990
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