New Molecules of Importance in the Prevention and Treatment of Acne: A Systematic Patent Review (2016-2020)
- Authors: Calderón-Pardo D.1, Serafini M.2, Alves I.3, Aragón D.1
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Affiliations:
- Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia
- Department of Pharmacy, Federal University of Sergipe
- Department of Pharmacy, Federal University of Bahia
- Issue: Vol 31, No 21 (2024)
- Pages: 3182-3197
- Section: Anti-Infectives and Infectious Diseases
- URL: https://j-morphology.com/0929-8673/article/view/644734
- DOI: https://doi.org/10.2174/0929867331666230817155906
- ID: 644734
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Full Text
Abstract
Background:Acne is a highly prevalent disease that mainly affects the pilosebaceous units associated with sebaceous glands, causing inflammatory skin lesions and affecting the self-esteem, mental health, and quality of life of those who suffer from this disease. Different treatments exist today to prevent, reduce, and improve symptoms; however, over the years, there have been problems with bacterial resistance and slight effectiveness with prolonged use.
Objective:The purpose of this article is based on the review of patents of new products of principal topical administration for the treatment of acne in recent years 2016-2020, to evaluate and analyze novel synthetic molecules and semi-synthetics with potential therapeutic and preventive in the acne treatment.
Methods:A systematic review of patents was conducted through the official database of the European Patent Office - Espacenet, where the search focused on the keywords: \"acne and bacteria\" in the title or abstract. Only patents granted between the years 2016-2020 were included, with products having molecules with a synthetic and semi-synthetic origin, without considering natural, biological products or those used as diagnostic means.
Results:A total of 19 patents were selected, most with principally antimicrobial and antiinflammatory action, where the reduction in the appearance of resistance by C. acnes is verified, and its action is complemented by inhibiting the different pathophysiological mechanisms that lead to the worsening of the disease.
Conclusion:Novel approaches in the treatment and prevention of acne, mainly topically, are focused on the reduction of bacterial resistance and irritation compared to current treatments. The use of combined formulations provides better results with additional benefits, improving treatment times and patient adherence.
Keywords
About the authors
Daniela Calderón-Pardo
Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia
Email: info@benthamscience.net
Mairim Serafini
Department of Pharmacy, Federal University of Sergipe
Email: info@benthamscience.net
Izabel Alves
Department of Pharmacy, Federal University of Bahia
Email: info@benthamscience.net
Diana Aragón
Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia
Author for correspondence.
Email: info@benthamscience.net
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