An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review


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Abstract

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs.

About the authors

Sahar Hamedani

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science

Email: info@benthamscience.net

Makan Pourmasoumi

Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences

Email: info@benthamscience.net

Gholamreza Askari

Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Mohammad Bagherniya

Nutrition and Food Security Research Center and Department of Community Nutrition, Isfahan University of Medical Sciences

Email: info@benthamscience.net

Thozhukat Sathyapalan

Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull

Email: info@benthamscience.net

Amirhossein Sahebkar

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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