EXPERIMENTAL SUBSTANTIATION OF MODELING OF ABSCESSES OF VARIOUS LOCALIZATIONS

Abstract

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Background. The problem of experimental and urgent purulent surgery is the search for new ways of modeling and effective minimally invasive treatment of abscesses of various localizations. Modeling the delimited purulent cavity in the liver, abdomen and soft tissues remains an unresolved problem, despite the many methods of creating abscesses in the literature. Aim. The aim of the study was to simulate purulent abscesses of the liver, soft tissues and abdominal cavity. Material and Methods. In an experiment on 20 rabbits of the Chinchilla breed and 40 white laboratory rats, modeling of liver abscesses (20), soft tissues (20) and abscesses in the right ileal region (20) of the abdomen was performed. Initially, a cystic cavity was created by introducing a modernized Fogerty and Foley catheter with a balloon inflated to 2 ml through the trocar under ultrasound control, at the distal end, while the end of the catheter was covered with skin doppler. Five days later, the balloon was emptied and the catheter was removed. The formation of a purulent abscess involved the injection of a suspension of Staphylococcus aureus with a microbial load of 2 ml×106 cfu in a formed aseptic cavity (Patent for invention No. 2601378 on November 14, 2016). Results and Discussion. The obtained models of suppurative abscesses in the liver, abdomen and soft tissues had corresponding clinical characteristics of the delimited abscess, which was confirmed by instrumental, pathomorphological and microbiological studies. On the fifth-sixth day after infection of the cavity a model of a classical purulent abscess was obtained. Conclusions. The proposed method for modeling abscesses in the liver, abdomen and soft tissues is low-traumatic, provides a guaranteed formation of abscess, does not require any complicated manipulation and expensive technical equipment.