MANAGING MICROCIRCULATORY DISORDERS IN MOUSE MODEL OF ILEUS WITH OPIOID PEPTIDE

Abstract

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Background. Ileus is a formidable complication of various diseases of the abdominal cavity organs and the cardiovascular system and may require surgical treatment. Aim. The pathogenesis involves a violation of the microcirculation of the intestinal wall that is rich in lymphatic vessels. Material and Methods. Studies were carried out on white mongrel male rats (n=219) weighing 50-250 g underwent surgical removal of small intestinal obstruction after intraperitoneal injection of a lymph-stimulators direct agonist delta opioid receptors, peptide number 171 in the anastomosis and adjacent tissues and the control group. Biomicroscopy of mesentery of small intestine of rat and registration of contractile activity of lymphatic microvessels was carried out using luminescent microscope. Results and Discussion. The use of peptide number 171 in treatment of ileus restored microcirculation, reduced edema and damage to the tissue of the small intestine and allowed to increase the survival rate of animals irrespective of weight. Conclusions. Lymph-stimulators direct agonist delta opioid receptors, peptide number 171, helps to reduce the manifestations of ileus, improves microcirculation, prevents damage to the wall of the small intestine. The use of peptide number 171 increases the survival rate of animals with its preliminary introduction.