EFFECT OF ALPHA LIPOIC ACID ON RECOVERY OF FUNCTION AFTER DELAY REPAIR OF THE SCIATIC NERVE

Abstract

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Background. Contrary to experimental studies routin clinical studies peripheral nerve cut does not performed immediately after injury. Therefore there is a delay for reconstruction of the peripheral nerves. Aim. In the present study we aimed to study effect of lipoic acid treatment in delay repair model of peripheral nerve to understand how axonal pathfinding and functional recovery will be affected. Material and Methods. For this purpose, a total number of 70 Wistar rats were used for this purpose and divided into seven groups Grup 1 (Control), Group 2 (Sham), Group 3 (Primary repair), Group 4 (Delay repair), Group 5 (Primary repair+LA), Group 6 (Delay repair+LA) ve Group 7 (Delay repair+delay LA treatment). Animals which treatad with alpa lipoic acid were given 50 mg/kg/day dose of alpha lipoic acid. Results and Discussion. Sciatic nerve regeneration was evaluated by walking track analysis, pinch test, light and electron microscopy and antioxidant effect of Alpha lipoic acid (+) was evaluated by biochemical analysis. We found that there was a beneficial effect of lipoic acit treatment on sciatic nerve after delay repait. However, this beneficial effect has been affected from structure of the sciatic nerve which detoiriated due to delay repair. Conclusions. We think that our study will add valuable knowledge to the literature on the understanding of the nerve regeneration.