THE DEPENDENCE OF THE ABNORMALITIES OF SPERMATOGENESIS ON THE TIMING OF RADIATION THERAPY

Abstract

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Background. The use of modern methods of anticancer therapy leads to an increase in the life expectancy of patients Aim. Analysis of the severity of spermatogenesis disorders depending on the timing of radiation therapy. Material and Methods. A retrospective analysis of spermograms of patients (n=45) who received radiation therapy up to 2 Gr was carried out. All patients underwent standard laboratory methods (General blood and urine tests, blood biochemistry). Spermogram was performed in dynamics according to WHO standards (2010) in 3, 6, 9, 12, 24 months after radiation therapy. As part of the art program, 9 (20%) patients underwent testicular biopsy (micro TESE) followed by morphological examination of testicular tissue. Results and Discussion. All patients (n=45) were aged 23±4.8 years. So they were men of reproductive age. Clinical data of the underlying disease (testicular cancer) we evaluated retrospectively. Stages of the disease were distributed as follows: stage T1 - in 13 (28.8%) patients, T2 - in 20 (44.4%), T3 - in 11 (24.4%), T4 - in 1 (2.2%) patients with histological examination, the following forms were established: seminoma (benign neoplasm) in 24 (53.3%) patients; non-hemic tumors in the first group in 21 (46.7%). The most pronounced changes in the spermogram (sperm concentration, total sperm count) are observed during 3-9 months after radiation therapy. Conclusions. Patients after radiotherapy of oncological diseases it is necessary to appoint a drug therapy to restore spermatogenesis for min 6-9 months. Preliminary cryopreservation of sperm is required before radiation therapy in men of reproductive age.