LOCALIZATION OF ALPHA-SYNUCLEIN IN RAT BRAIN AND ITS INTERRELATION WITH THE DOPAMINERGIC STRUCTURES
- Authors: Voronkov D.N.1, Khudoyerkov R.M.1, Sal’nikova O.V.1, Sobolev V.B.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 151, No 1 (2017)
- Pages: 7-13
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/397785
- DOI: https://doi.org/10.17816/morph.397785
- ID: 397785
Cite item
Abstract
Localization of alpha-synuclein (α-Syn - the protein found in Lewy bodies in Parkinson’s desease) and tyrosine hydroxylase (a marker of dopamin- and noradrenergic neurons) were studied by immunohistochemical methods in brain structures of intact Wistar rats (n = 5) and compared with the data obtained after destruction of substantia nigra (n = 3). Localization of α-Syn in synaptic structures of basal ganglia corresponded to cortico-striatal and strio-nigral projections, which was confirmed experimentally. In the cell bodies of dopamin- and noradrenergic neurons, α-Syn was found in the substantia nigra, locus coeruleus and in the dorsal nucleus of nervus vagus, prone to neurodegeneration in in Parkinson’s desease. High α-Syn content was also found in sensory olfactory neurons and glomeruli of the olfactory bulbs.
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About the authors
D. N. Voronkov
Research Center of Neurology
Email: voronkovdm@gmail.com
R. M. Khudoyerkov
Research Center of Neurology
Email: rolfbrain@yandex.ru
O. V. Sal’nikova
Research Center of Neurology
Email: fial88@mail.ru
V. B. Sobolev
Research Center of Neurology
Email: sobolevalera@gmail.com
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