ORGANIZATION OF CONNECTIONS OF THE ROSTROMEDIAL TEGMENTAL NUCLEUS WITH THE STRUCTURES OF MORPHO-FUNCTIONAL SYSTEM OF BRAIN BASAL GANGLIA IN DOGS



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Spatial organization of projections of the rostromedial tegmental nucleus (RMTN) on functionally different segments of the basal ganglia structures was studied in dogs (n=25) by the method of retrograde axonal transport of horseradish peroxidase. The connections detected between the RMTN limbic segments and the limbic segments of the zona incerta and the pallidum indicate the possibility of segregated conduction of limbic information. In addition, it was found that the projections of the limbic medial and motor lateral RMTN segments overlap in pedunculopontine and entopeduncular nuclei with the incoming fibers from functionally different neuronal nuclei. The presence of marked sparse-branching, long-axonal “reticular” RMTN neurons projecting to the studied structures also indicates the integrative function of this nucleus. In fact, the morphological substrate of information processing in the basal ganglia morpho-functional system that underlies their functioning, was analyzed.

Full Text

Restricted Access

About the authors

A. I. Gorbachevskaya

RAS I. P.Pavlov Institute of Physiology

Email: aig@infran.ru

References

  1. Горбачевская А. И. Организация проекций структур морфофункциональной системы базальных ганглиев на отдельные подструктуры глубокого мезенцефалического ядра мозга собаки // Морфология. 2012. Т. 142, вып. 6. С. 10-14.
  2. Горбачевская А. И. Анализ проведения информации и её интеграции в проекционных истемах, связывающих базальные ганглии с ростромедиальным тегментальным ядром мозга собак // Рос. физиол. журн. им. И. М. Сеченова. 2014. Т. 100, вып. 5. С. 542-554.
  3. Горбачевская А. И.,Чивилёва О. Г. Морфологический анализ путей проведения информации в базальных ганглиях млекопитающих // Успехи физиол. наук. 2003. Т. 34, вып.2. С. 46-63.
  4. Горбачевская А. И., Чивилёва О. Г. Структурная организация педункулопонтийного ядра покрышки среднего мозга собаки // Морфология. 2004. Т. 126, вып. 5. С. 11-15.
  5. Горбачевская А. И., Чивилёва О. Г. Структурная организация неопределённой зоны промежуточного мозга собаки // Морфология. 2007. Т. 128, вып. 3. С. 11-15.
  6. Bolam J. P., Hanley J. J., Booth P.A. C., Bevan M. D. Synaptic orga nization of the basal ganglia // J. Anat. 2000. Vol. 196. P. 527-542.
  7. Dua-Sharma S., Sharma K. N., Jacobs H. L. The Canine Brain in Stereotaxic Coordinates. Cambridge, Massachusetts, London: MIT Press, 1970.
  8. Haber S. N. Functional anatomy and physiology of the basal ganglia: non-motor functions. In: Deep Brain Stimulation in Neurological and Psychiatric Disorders. Totowa, N. J.: Humana Press, 2008. P. 33-62.
  9. Heise C. E., Mitrofanis J. Evidence for a glutamatergic projection from the zona incerta to the basal ganglia of rats // J. Comp. Neurol. 2004. Vol. 468, № 3. P. 482-495.
  10. Jbabdi S., Sotiropoulos, Behrens T. E. The topographic connectome // Curr. Opin. Neurobiol. 2013. Vol. 23, № 2. P. 207-215.
  11. Jhou T.C., Geisler S., Marinelli M., Degarmo B. A. The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta // J. Comp. Neurol. 2009. Vol. 513, № 6. P. 566-596.
  12. Jhou T. C., Fields H. L., Baxter M. G., Saper C. B., Holland P. C. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses // Neuron. 2009. Vol. 61, № 3. P. 786- 800.
  13. Lavezzi H. N., Zahm D. S. The mesopontine rostromedial tegmental nucleus: An integrative modulator of the reward system // Basal Ganglia. 2011. Vol. 1, № 4. P. 191-200.
  14. Mesulam M. M. Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents // J. Histochem. Cytochem. 1978. Vol. 26, № 2. P. 106-117.
  15. Parent A. Comparative Neurobiology of the Basal Ganglia. N.Y.: John Wiley & Sons. 1986.
  16. Plaha P., Khan S., Javed S., Gill S. S. Caudal zona incerta as an alternative target for the treatment of tremor with deep brain stimulation // Eur. Neurol. Rev. 2009. Vol. 4, № 1. P. 91-96.
  17. Rodriguez M., Abdala P., Barroso-Chinea P., Gonzalez-Hernandez T. The deep mesencephalic nucleus as an output center of basal ganglia: morphological and electrophysiological similarities and electrophysiological similarities with the substantia nigra // J. Comp. Neurol. 2001. Vol. 438, № 3. P. 12-31.
  18. Takakusaki K. Forebrain control of locomotor behaviors // Brain Research Reviews. 2008. Vol. 57, № 1. P. 192-198.
  19. Wichman T., DeLong M. R. Deep-brain stimulation for basal ganglia disorders // Basal Ganglia 2011. Vol. 1, № 2. P. 65-77.
  20. Wilson D. I., MacLaren A.A, Winn P. On the relationships between the pedunculopontine tegmental nucleus, corticostriatal architecture, and the medial reticular formation. In: Basal Ganglia IX. Adv. Behav. Biol., 2009. Vol. 58. P. 143-157.
  21. Woolf N. J. Global and serial neurons form a hierarchically arranged interface proposed to underlie memory and cognition // Neuroscience. 1996. Vol. 74, № 3. P. 625-651.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies