COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN EXPERIMENTAL THROMBOSIS AND LIGATION OF THE VEIN



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Abstract

The microcirculatory disturbances on Day 4, weeks 1, 2, 3, 4 and 5 after a femoral vein thrombosis and its ligation were examined in 155 and 153 Wag male rats respectively in sections stained with hematoxylin-eosin. It was found that after thrombosis, a large area of vein was affected together with collateral vessels, moreover, through these collaterals the thrombin spread retrogradely far into the tissues, blocking venous drainage even through small vessels. Simultaneously, lymphatic vessels were affected by thrombosis. Patency of the main vein after thrombosis was quickly restored, but microcirculatory disturbances within a significant tissue region persisted for a long time. After vein ligation, the obstruction of a vessel was local, and the stasis was quickly compensated by pre-existing collaterals. No significant changes of regional lymphatic system were detected, while some evidence of compensation of venous drainage insufficiency was found. Also, no considerable changes of vessels in muscular tissue were found. At the same time, extensive longstanding hemorrhages persisted in the paravasal tissues that were caused by the processes of reorganization of collateral vessels wall of and the phenomena of sclerosis were more pronounced.

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About the authors

I. V. Maiborodin

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

V. V. Morozov

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

A. A. Anikeyev

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

N. F. Figurenko

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

R. V. Maslov

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

G. A. Chastikin

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

Email: imai@mail.ru

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