STRUCTURAL CHANGES OF SKELETAL MUSCLE IN LOCAL HYPERTENSIVE ISCHEMIC SYNDROME
- Authors: Tkach A.V.1, Plotkin A.V.1
-
Affiliations:
- V. I. Vernadskiy Crimean Federal University
- Issue: Vol 153, No 1 (2018)
- Pages: 49-54
- Section: Articles
- Submitted: 09.05.2023
- Published: 15.01.2018
- URL: https://j-morphology.com/1026-3543/article/view/398190
- DOI: https://doi.org/10.17816/morph.398190
- ID: 398190
Cite item
Abstract
Objective - to study the peculiarities of structural changes of skeletal muscle in animal model of local hypertensive ischemic syndrome. Material and methods. Histological examination of thigh muscles from adult rabbits of both sexes was performed in normal animals and at various time intervals after application of a pneumatic tourniquet on the femoral upper third for 4 hrs under 80-100 mm Hg pressure (3 control and 14 experimental animals). Results. A pneumatic tourniquet with an exposure of 4 hrs caused thigh muscle edema, muscle fiber structural homogenization and contraction. Starting on day 7 after removal of the pneumatic tourniquet, the ischemic muscles were characterized by a progressive proliferation of connective tissue cells with the development of fibrous tissue and the intensification of degenerative changes in muscle fibers. Conclusions. Exposure of skeletal muscle of rabbit thigh to a local hypertensive ischemia for 4 hrs under 80-100 mm Hg pressure resulted in the development of scar-fibrotic degeneration of soft tissues, characteristic for ischemic syndrome.
Full Text
About the authors
A. V. Tkach
V. I. Vernadskiy Crimean Federal University
Email: AndreyT_71@mail.ru
Department of Traumatology and Orthopedics, S. I. Georgiyevskiy Medical Academy
A. V. Plotkin
V. I. Vernadskiy Crimean Federal UniversityDepartment of Traumatology and Orthopedics, S. I. Georgiyevskiy Medical Academy
References
- Лябах А. П., Бруско А. Т. Морфологические изменения мышц при ишемической контрактуре стопы // Проблемы остеологии. 2002. Т. 5, № 1. С. 14-18.
- Страфун С. С., Бруско А. Т. Профилактика и лечение МГИС // Ортопед., травматол. и протезир. 1995. № 1. С. 33-37.
- Страфун С. С., Бруско А. Т., Лискина И.B. Взаимосвязь внутрикостного кровяного давления с подфасциальным давлением // Bеcтн. травматол., ортопед. и протезир. 2005. № 2. С. 12-15.
- Страфун С. С., Бруско А. Т., Лябах А. П. Профилактика, диагностика и лечение ишемических контрактур кисти и стопы. Киев: Стилос, 2007. 264 с.
- Страфун С. С., Ткач А. В., Долгополов А. В. Проблемы диагностики и лечения местного гипертензионного ишемического синдрома // Таврическ. мед.-биол. вестн. 2011. Т. 14, № 1. С. 146-153.
- Страфун С. С., Ткач А. В., Плоткин А В., Дворский А. Г. Алгоритм ранней диагностики и тактика лечения компартментсиндрома // Медицина катастроф. 2015. № 1. С. 34-39.
- Страфун С. С., Ткач А. В., Решетилов Ю. И., Дмитриева С. Н. Сравнительные способы диагностики местного гипертензионно-ишемического синдрома // Травма. 2009. Т. 10, № 2. С. 226-229.
- Duehrkop C., Rieben R. Refinement of tourniquet-induced peripheral ischemia/reperfusion injury in rats:comparison of 2 h vs 24 h reperfusion // Lab. Anim. 2014. Vol. 48, №2. P.143-154.
- Mansour Z., Charles A. L., Bouitbir J., Pottecher J., Kindo M., Mazzucotelli J. P., Zoll J., Geny B. Remote and local ischemic postconditioning further impaired skeletal muscle mitochondrial function after ischemia-reperfusion // J. Vasc. Surg. 2012. Vol. 56, №3. P. 774-782.
- Matsen F.A. Compartmental syndromes. New York, San Francisсo: Grune & Stratton, 1980. 129 p.
- Ozkan H., Ekinci S., Uysal B., Akyildiz F., Turkkan S., Er sen O., Koca K., Seven M. M. Evaluation and comparison of the effect of hypothermia and ozone on ischemia-reperfusion in jury of skeletal muscle in rats // J. Surg Res. 2015. Vol. 196, №2. P. 313-319
- Turóczi Z., Fülöp A., Lukáts A., Garbaisz D., Lotz G., Harsányi L., Szijártó A. Postconditioning protects skeletal muscle against a long-lasting vascular occlusion // J. Invest. Surg. 2014. Vol. 27, №5. P. 282-290.
- Volkmann R. Die ischaemischen Muskellähmungen und Kon trakturen // Zentralbl Chir. 1881. Bd. 8. P. 801-803.
- Whitesides Т. Е., Hahey T. C., Morimoto K., Harada H. Tissue pressure measurements as a determinant for the need of fasciotomy // Clin. Orthop. 1975. Vol. 113, № l. P. 43-51.