PARTICIPATION OF SEROTONIN IN THE MECHANISMS OF THE FORMATION OF TRIGEMINAL MOTOR NUCLEUS
- Authors: Khozhay L.I.1, Otellin V.A.1, Khozhai LI1, Otellin VA1
-
Affiliations:
- Issue: Vol 142, No 5 (2012)
- Pages: 23-26
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398539
- DOI: https://doi.org/10.17816/morph.398539
- ID: 398539
Cite item
Abstract
The formation of trigeminal motor nucleus (TMN) was studied in the early postnatal period in 21 female Wistar rats which received the serotonin biosynthesis inhibitor para-chloro-phenylalanine at prenatal Day 16 (the period of serotoninergic system formation). It was shown that the serotonin deficit during the prenatal period in rats resulted in the changes of TMN structural organization. In the early postnatal period, the delay of neuropil development, the reduction of cell body size with the partial loss of Nissl substance in some of the neurons, the presence of degenerating neurons with the signs of hyperchromatosis in all the parts of the nucleus, especially in TMN ventromedial part, were detected. At later stages, the destruction of motoneurons became slower, though some of them had morphological abnormalities. With the increase of the postnatal age (by Day 20) the number of motor neurons decreased, apparently, as a result of the gradual intensification of cell death. Simultaneously with the motor neuron degeneration in TMN parts studied, the astrocytic gliosis was observed.
About the authors
Lyudmila Ivanovna Khozhay
Email: astarta0505@mail.ru
Vladimir Aleksandrovich Otellin
L I Khozhai
V A Otellin
References
- Коржевский Д. Э. и Отеллин В. А. Иммуноцитохимическое выявление астроцитов в срезах головного мозга в сочетании с окраской по Нисслю. Морфология, 2004, т. 125, вып. 3, с. 100-102.
- Попова Н. К., Никулина Э. М., Арав В. Н. и Кудрявцева Н. Н. О роли серотонина в одном из видов агрессивного поведения. Физиол. журн., 1975, т. 61, № 2, с. 183-186.
- Хожай Л. И., Пучков В. Ф. и Отеллин В. А. Влияние дефицита серотонина на эмбриональное развитие млекопитающих. Онтогенез, 1995, т. 26, № 5, с. 350-356.
- Lazarov N. E. Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus. Prog. Neurobiol., 2002, v. 66, p. 19-59.
- Nakamura M., Yasuda K., Hasumi-Nakayama Y. et al. Colocalization of serotonin and substance P in the postnatal rat trigeminal motor nuclrus and its surroundings. Int. J. Dev. Neurosci., 2006, v. 24, № 1, p. 61-64.
- Tanaka-Gomi N., Yasuda K., Nakamura M. et al. Postnatal changes in 5HT and NK1 receptors in rat trigeminal motor nucleus and surroundings. Int. J. Dev. Neurosci., 2007, v. 25, № 7, p. 427-432.
- Yeung L. Y., Kung H. F. and Yew D. T. Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control agematched and Alzheimer individuals. Age, 2010, v. 32, № 4, p. 483-495.