THE PECULIARITIES OF THE PULMONARY ACINUS STRUCTURE IN THE RESIDENTS OF WESTERN SIBERIA
- Authors: Shishkin G.S.1, Ustyuzhaninova N.V.1, Shishkin GS1, Ustyuzhaninova NV1
-
Affiliations:
- Issue: Vol 142, No 5 (2012)
- Pages: 54-58
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398561
- DOI: https://doi.org/10.17816/morph.398561
- ID: 398561
Cite item
Abstract
Pulmonary acinus architectonics and parameters were studied in six men aged 19-27 years that permanently lived in the city of Novosibirsk. The study was conducted on the serial histological sections by using morphometry and volumetric graphic reconstruction of the acini. In a typical acinus, three generations of the respiratory bronchioles, four generations of the alveolar ducts, and one generation of the alveolar sacs (AS) were found. All the intraacinar components branched in the form of dichotomy, most commonly, irregular. It was shown that the acini were regularly asymmetrical, 32% of branches of the alveolar ducts of the second order had no continuation and ended with AS. In the same way, two thirds of the third order alveolar ducts also continued into AS, i. e. about 40% of branches are rudimentary. Intra-acinar path from the first alveoli in the respiratory bronchioles to the terminal alveoli is equal to 7.2±1.0 mm. The peculiar feature of the acinus of the Siberian residents is an increased transitional zone and a distal shift of respiratory zone by one generation of branches in the direction from the conducting airways, which reduces its cooling during breathing cold air in winter.
About the authors
Gennadiy Sergeevich Shishkin
Nina Vital'evna Ustyuzhaninova
Email: nvu@physiol.ru
G S Shishkin
N V Ustyuzhaninova
References
- Вейбель Э. Р. Морфометрия легких человека. М., Медицина, 1970.
- Шишкин Г. С., Гончаров В. В., Валицкая Р. И. и др. Структурная организация легочной дольки человека. Морфология, 1999, т. 116, вып. 4, с. 45-47.
- Berend N., Rynell A. C. and Ward H. E. Structure of a human pul monary acinus. Torax, 1991, v. 46, № 2, p. 117-121.
- Ciurea D. and Gil J. Morphometric study of human alveolar ducts based on serial sections. J. Appl. Physiol., 1989, v. 67, № 6, p. 2512-2521.
- Felici M., Filoche M., Straus C. et al. Diffusional screening in real 3D human acini - a theoretical study. Respir. Physiol. Neurobiol., 2005, v. 145, № 2-3, p. 279-293.
- Haefeli-Bleuer B. and Weibel E. Morphometry of the Human Pulmonary Acinus. Anat. Rec., 1988, v. 220, № 4, p. 401-414.
- Horsfield K. and Cumming G. Morphology of the bronchial tree in men. J. Appl. Physiol., 1968, v. 24, № 3, p. 373-383.
- Kumar H., Tawhai M. H. and Hoffman E. A. The effects of geometry on airflow in the acinar region of the human lung. J. Biomech., 2009, v. 42, № 11, p. 1635-1642.
- Leeming A. and Schroter R. A model morphology of the pulmonary acinus. Proc. Inst. Mech. Eng. H., 2008, v. 222, № 4, p. 429-437.
- Litzlbauer H. D., Korbel K., Kline T. L. et al. Synchrotron-based micro-CT imaging of the human lung acinus. Anat. Rec., 2010, v. 293, № 90, p. 1607-1614.
- Ochs M., Nyengaard J.R, Jung A. et al. The number of alveoli in the human lung. Am. J. Respir. Crit. Care Med., 2004, v. 169, № 1, p. 120-124.
- Parameswaran H., Bartolák-Suki E., Hamakawa H. et al. Threedimensional measurement of alveolar airspace volumes in normal and emphysematous lungs using micro-CT. J. Appl. Physiol., 2009, v. 107, № 2, p. 583-582.
- Rodriguez M., Bur S. and Favre A. Pulmonary acinus: geometry and morphometry of the peripheral airway system in rat and rabbit. Am. J. Anat., 1987, v. 180, № 2, p. 143-145.
- Sapoval B., Filoche M. and Weibel E. R. Smaller is better - but not too small: a physical scale for the design of the mammalian pulmonary acinus. Proc. Natl. Acad. Sci. USA, 2002, v. 99, № 16, p. 10411-10416.
- Scarpelli E. M. The alveolar surface networks new anatomy and physiological significance. Anat. Rec., 1998, v. 251, № 4, p. 491-527.
- Tsuda A., Filipovic N., Haberthür D. et al. Finite element 3D reconstruction of the pulmonary acinus imaged by synchrotron X-ray tomography. J. Appl. Physiol., 2008, v. 105, № 3, p. 964-976.
- Weibel E. R. What makes a good lung? Swiss. Med. Wkly., 2009, v. 139, № 27-28, p. 375-386.
- Weibel E. R., Sapoval B. and Filoche M. Design of peripheral airways for efficient gas exchange. Respir. Physiol. Neurobiol., 2005, v. 148, № 1-2, p. 3-21.