PECULIARITIES OF TISSUE REACTIONS TO IMPLANTATION OF NON-DEGRADABLE SURGICAL MATERIALS



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Abstract

The method of light microscopy was used to study the reactions of the surrounding tissues to the implantation of non-degradable surgical materials (prolene 3/0 thread made from polypropelene, the composite grid made from polypropelene or polyester with polylactic acid) in the subcutaneous adipose tissue of rats 1, 2, 6 and 12 months after grafting. No less than 6 rats were examined in every time point. It was shown that the tissue reactions to implantation of different non-degradable surgical materials follows the general pattern, characteristic of wound process and foreign body reaction. By the first month of observation in both groups of animals the stage of traumatic perifocal inflammation was replaced by the proliferative phase with the formation of new blood vessel and connective tissue. The tendency to reduction of the activity of productive inflammation was observed from the 1st to the 12th month together with the increased fibrous scar transformation of the granulation tissue.

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About the authors

I. V. Kuznetsova

Institute of Chemical Biology and Fundamental Medicine RAS Siberian Branch

The Center of New Medical Technologies

I. V. Maiborodin

Institute of Chemical Biology and Fundamental Medicine RAS Siberian Branch

The Center of New Medical Technologies

A. I. Shevela

Institute of Chemical Biology and Fundamental Medicine RAS Siberian Branch

The Center of New Medical Technologies

M. I. Barannik

Institute of Chemical Biology and Fundamental Medicine RAS Siberian Branch

The Center of New Medical Technologies

A. A. Manayev

Institute of Chemical Biology and Fundamental Medicine RAS Siberian Branch

The Center of New Medical Technologies

V. I. Maiborodina

Institute of Chemical Biology and Fundamental Medicine RAS Siberian Branch

The Center of New Medical Technologies

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