Email this article PLACENTA OF NORMAL WOMEN AND OF PATIENTS WITH BRONCHIAL ASTHMA OF VARIOUS DEGREES OF SEVERITY (IMMUNOHISTOCHEMICAL AND HISTO LO GICAL STUDY)
- Authors: Zubzhitskaya L.B.1, Shapovalova Y.A.1, Lavrova O.V.2, Dymarskaya Y.R.3, Arzhanova O.N.1
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Affiliations:
- D. O. Ott RAMS North-Western Branch Scientific Research Institute of Obstetrics and Gynecology
- Scientific Research Institute of Pulmonology
- I. P. Pavlov First St. Petersburg State Medical University
- Issue: Vol 145, No 2 (2014)
- Pages: 46-52
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398752
- DOI: https://doi.org/10.17816/morph.398752
- ID: 398752
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Abstract
The aim of the study was to examine the immunomorphological features and expression of immunohistochemical markers that indicate the presence of immune inflammation in the placenta in normal pregnancy and in pregnancy complicated by bronchial asthma (BA) of varying degrees of severity. The of 80 samples of placenta from patients with BA were studied immunohistochemically and histologically to demonstrate the fixation of С3 fraction of complement, fibrinogen, IL-4, IL-6, IgA, IgM, IgG, and the expression of CD31, CD35, CD57 and CD83 molecules. The largest number of immune deposits fixed in the placenta and damaging the structures of the placental barrier (vascular endothelium and syncytiotrophoblast membranes) was found in women with moderate to severe BA. Their precipitation lead to the development of immunopathological process in the placenta and could result in placental insufficiency, adversely affecting the course of pregnancy and childbirth. The presence of pathogenic immune complexes in the placenta and the detection of antigen-presenting cells in areas of immunological inflammation in the placenta of women with BA are associated with the unfavorable course of pregnancy, parturition and could be a predictor of the possible development of allergic diseases in children.
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About the authors
L. B. Zubzhitskaya
D. O. Ott RAMS North-Western Branch Scientific Research Institute of Obstetrics and Gynecology
Email: lzubzhitskaya@mail.ru
Ye. A. Shapovalova
D. O. Ott RAMS North-Western Branch Scientific Research Institute of Obstetrics and Gynecology
Email: e.shapovalova@mail.ru
O. V. Lavrova
Scientific Research Institute of Pulmonology
Email: loverova@bk.ru
Yu. R. Dymarskaya
I. P. Pavlov First St. Petersburg State Medical University
Email: julia_dym@mail.ru
O. N. Arzhanova
D. O. Ott RAMS North-Western Branch Scientific Research Institute of Obstetrics and Gynecology
Email: arjanova_olga@mail.ru
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).