CHANGES IN THE MUCOUS MEMBRANES OF THE ORAL CAVITY IN CHRONIC RENAL FAILURE (EXPERIMENTAL STUDY)



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Abstract

Methods of light microscopy were used to study the morphological changes of the oral cavity mucosa in rats (n=48) in chronic renal failure (CRF) of various degrees. It was found that after 6 months of modeling of mild and moderate CRF, lamina propria of the oral cavity mucous membranes was diffusely infiltrated with leukocytes. At the same time, relative density of the distribution of the components of blood and lymphatic vascular bed was increased. In severe CRF, the atrophy and hyperkeratosis of the epithelium of the oral cavity mucous membrane developed, while the lamina propria demonstrated sclerosis and significant increase of leukocyte (primarily neutrophil and monocyte) and macrophage numerical density with the formation of small leukocyte infiltrates. In addition, in moderate and severe CRF, the number of eosinophils and plasma cells was increased in the lamina propria which indicates the possible presence of allergic component in the initiation and maintenance of its inflammation.

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About the authors

I. V. Maiborodin

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

Email: imai@mail.ru

I. M. Minikeyev

Scientific Center of Reconstructive and Restorative surgery

S. A. Kim

Kyrgyz State Medical Institute for Retraining and Qualifications Improvement

T. M. Ragimova

RAS Siberian Branch Institute of Chemical Biology and Fundamental Medicine

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