INTERSTITIAL CELLS OF CAJAL IN THE SMOOTH MUSCLE TISSUE OF THE GALLBLADDER AND BILE DUCTS
- Authors: Zashikhin A.L.1, Liubeznova A.Y.1, Agafonov Y.V.1
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Affiliations:
- Northern State Medical University
- Issue: Vol 148, No 4 (2015)
- Pages: 24-27
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398892
- DOI: https://doi.org/10.17816/morph.398892
- ID: 398892
Cite item
Abstract
Interstitial cells of Cajal (ICC) in the gallbladder and in different parts of the biliary tract were identified in adult guinea pigs by means of immunocytochemical reactions to specific marker of these cells - C-kit receptor tyrosine kinase (CD117) and electron microscopic analysis. It was shown that C-kit-positive cells were localized in the muscular component of the gallbladder wall and the various parts of the bile ducts. In the gallbladder wall their density was higher than in the bile ducts. ICC have numerous processes, and are characterized by the absence of the components of the contractile apparatus. They possess the capacity to form tight membrane contacts with smooth myocytes.
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About the authors
A. L. Zashikhin
Northern State Medical University
Email: zashihin2@atknet.ru
Department of Histology, Cytology and Embryology
A. Yu. Liubeznova
Northern State Medical UniversityDepartment of Histology, Cytology and Embryology
Yu. V. Agafonov
Northern State Medical University
Email: profALZ@yandex.ru
Department of Histology, Cytology and Embryology
References
- Бобрышев Ю. В., Тран Д., Киллингворс М. С. и др. Межклеточные контакты интерстициальных клеток Кахаля в зоне ауэрбахова сплетения в пищеводе человека // Механизмы функционирования висцеральных систем. СПб.: изд. Ин-та физиологии им. И. П. Павлова РАН, 2009. С. 62-63.
- Зашихин А. Л., Селин Я. Висцеральная гладкая мышечная ткань. Архангельск: Умео; М.: изд. СГМУ, 2001.
- Зашихин А. Л., Селин Я., Агафонов Ю. В. Морфофункциональная характеристика пейсмейкеров в гладкой мышечной ткани // Морфология. 1999. Т. 115, вып. 2. С. 46-50.
- Hashitani H., Lang R. J. Functions of ICC-like cells in the urinary tract and male genital organs // J. Cell. Mol. Med. 2010. Vol. 14, № 6A. P. 1199-1211.
- Huanga Y., Meia F., Yua В. et al. Distribution of the interstitial Cajal-like cells in the gallbladder and extrahepatic biliary duct of the guinea-pig // Acta Histochem. 2009. Vol. 111, № 2. P. 157-165.
- Huizinga J. D., Faussone-Pellegrini M. S. About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract // J. Cell. Mol. Med. 2005. Vol. 9, № 2. P. 468-473.
- Kito Y., Ward S. M., Sanders K. M. Pacemaker potentials generated by interstitial cells of Cajal in the murine intestine // Am. J. Physiol. Cell. Physiol. 2005. Vol. 288, № 3. P. 710-720.
- Lavoie B., Balemba O. B., Nelson M. T. et al. Morphological and physiological evidence for interstitial Cell. of Cajal-like cells in the guinea pig gallbladder //J. Physiol. 2007. Vol. 579 (Pt. 2). P. 487-501.
- Lee H. T., Henning G. W., Fleming N. W. et al. The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine // Gastroenterology. 2007. Vol. 132, № 5. P. 1852-1865.
- Popescu L. M., Ciontea S. M., Cretoiu D. et al. Novel type of interstitial Cell. (Cajal-like) in human fallopian tube // J. Cell. Mol. Med. 2005. Vol. 9, № 2. P. 479-523.
- Torihashi S., Gerthoffer W. T., Kobayashi S., Sanders K. M. Identification and classification of interstitial cells in the canine proximal colon by ultrastructure and immunocytochemistry // Histochemistry. 1994. Vol. 101, № 3. P. 169-183.
- Rumessen J. J., Thuneberg L. Interstitial cells of Cajal in human small intestine. Ultrastructural identification and organization between the main smooth muscle layers // Gastroenterology. 1991. Vol. 100, № 5 (Pt. 1). P. 1417-1431.