Email this article EXPRESSION OF SEROTONIN TRANSPORT PROTEIN IN THE DORSAL RAPHE NUCLEUS IN THE EARLY POSTNATAL PERIOD IN RATS
- Authors: Khozhai L.I.1
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Affiliations:
- I. P.Pavlov Institute of Physiology
- Issue: Vol 148, No 4 (2015)
- Pages: 43-45
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398900
- DOI: https://doi.org/10.17816/morph.398900
- ID: 398900
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Abstract
In this work an expression of serotonin transport protein (5-HTT) was studied in the dorsal raphe nucleus (DRN) - in its dorsal, ventral and lateral subnuclei in Wistar rats (n=15) during the early postnatal period. Histological methods and immunocytochemical staining demonstrating 5-HTT were used in the investigation. It was shown that at postnatal Day 5 major part of neurons of the subnuclei studied intensively expressed 5-HTT. However, by Day 10, the level of its expression decreased dramatically, but with age (by Day 20) the expression was increased once again. This was manifested by the augmentation of size of 5-НТТ-positive neuronal population, the increase in the density of plexus network of their processes. The detected changes of 5-HTT expression indicate the varying degrees of functional activity of serotonin in the DRN in the early postnatal period.
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About the authors
L. I. Khozhai
I. P.Pavlov Institute of Physiology
Email: astarta0505@mail.ru
Laboratory of the Nervous System Ontogenesis
References
- Bruning G., Liangos O., Baumgarten H. G. Prenatal development of the serotonin transrorter in mouse brain // Cell. Tiss. Res. 1997. Vol. 289, № 2. P. 211-221.
- Tao-Cheng J. H., Zhou F. C. Differential polarization of serotonin transporters in axons vs. soma-dendrites: an immunogold electron microscopy study // Neuroscience. 1999. Vol. 94. P. 821-830.
- Zhou F. C., Sari Y., Zhang J. K. Expression of serotonin transporter protein in developing rat brain // Dev. Brain Res. 2000. Vol. 119. P. 33-45.
- Zhou F. C., Tao-Cheng J. H., Segu L. et al. Serotonin transporters are located on the axons beyond the synaptic junction: anatomical and functional evidence // Brain Res. 1998. Vol. 805. P. 241-254.
- Zhou F. C., Xu Y., Bledsoe S. et al. Serotonin transporter anti bodies: production, characterization, and localization in the brain // Mol. Brain Res. 1996. Vol. 43. P. 267-278.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).