ORGANIZATION AND CYTOCHEMICAL FEATURES OF BARRIER STRUCTURES IN HUMANPLACENTA



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The aim of the present study was to investigate structural pattern of human placental barrier elements using light and electron microscopy and immunocytochemistry. Some important peculiarities of organization of the placental barrier were detected: difference in structure and amount of collagen IV in the basal lamina of endothelium and trophoblast, occurrence of smooth muscle actin in the capillary wall forming syncytiocapillary membranes. In the intercapillary stroma of terminal villi, both fibroblasts and macrophages but not myofibroblasts were found. Since smooth muscle cells and myofibroblasts are absent, pericytes are most likely cells to contain smooth muscle actin in the area of syncytiocapillary membranes.

About the authors

D E KORZHEVSKIY

RAMS Institute of Experimental Medicine

RAMS Institute of Experimental Medicine

V A OTELLIN

RAMS Institute of Experimental Medicine, I.P. Pavlov Institute of Physiology

RAMS Institute of Experimental Medicine, I.P. Pavlov Institute of Physiology

A A NEOKESSARIYSKIY

RAMS Institute of Experimental Medicine

RAMS Institute of Experimental Medicine

A N STARORUSSKAYA

RAMS D.O. Ott Institute of Obstetrics and Gynecology, St. Petersburg

RAMS D.O. Ott Institute of Obstetrics and Gynecology, St. Petersburg

N G PAVLOVA

RAMS D.O. Ott Institute of Obstetrics and Gynecology, St. Petersburg

RAMS D.O. Ott Institute of Obstetrics and Gynecology, St. Petersburg

References

  1. Беков Д.Б. и Павлова Т.В. Архитектоника и ультраструктура сосудов хориона плаценты человека. Морфология, 1992, т. 102, вып. 5, с. 129-139.
  2. Бобков В.М. Количественная характеристика компонентов плацентарного барьера женщин при неосложненной доношенной беременности. Арх. анат., 1979, т. 76, вып. 6, с. 80-83.
  3. Гуревич П.С., Бенхур Г., Шперлинг И.Д. и др. Иммунопатоморфология плацентарного барьера человека в I триместре беременности при воспалительных заболеваниях родовых путей. Арх. пат., 2005, т. 67, № 1, с. 6-9.
  4. Калашникова Е.П. Плацента человека и ее роль в норме и при патологии. Арх. пат., 1985, т. 47, № 1, с. 3-11.
  5. Милованов А.П. Патология системы мать-плацента- плод. М., Медицина 1999.
  6. Burton G.J. and Tham S.W. Formation of vasculo-syncytial membranes in the human placenta. J. Dev. Physiol., 1992, v. 18, № 1, p. 43-47.
  7. Hung T., Skepper J.N., Charnock-Jones D.S. and Burton G.H. Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ. Res., 2002, v. 90, № 12; p. 1274-1281.
  8. Kacemi A., Vervelle C., Uzan S. and Challier J.C. Immunostaining of vascular, perivascular cells and stromal components in human placental villi. Cell. Mol. Biol., 1999, v. 45, № 1, p. 101-113.
  9. Kim H.S., Cho J.H., Park H.W. et al. Endotoxin-neutralizing antimicrobal proteins of the human placenta. J. Immunol., 2002, v. 168, № 2, p. 2356-2364.
  10. Macara L., Kingdom J.C., Kohnen G. et al. Elaboration of stem villous vessels in growth restricted pregnancies with abnormal umbilical artery Doppler waveforms. Br. J. Obstet.Gynaecol., 1995, v. 102, № 10, p. 807-812.
  11. Syme M.R., Paxton J.W. and Keelan J.A. Drug transfer and metabolism by the human placenta. Clin. Pharmacokinet., 2004, v. 43, № 8, p. 487-514.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2006 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies