Email this article CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION
- Authors: Droblenkov AV1, Karelina NR1, Shabanov PD1, Droblenkov AV2, Karelina NR3, Shabanov PD4
-
Affiliations:
- St. Petersburg City Bureau of Forensic Medical Examination
- St. Petersburg State PediatricMedical Academy
- MedicalMilitary Academy
- Issue: Vol 136, No 6 (2009)
- Pages: 35-37
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399196
- DOI: https://doi.org/10.17816/morph.399196
- ID: 399196
Cite item
Open Access
Access granted
Subscription or Fee Access
Abstract
morphometric parameters in mesoaccumbocingulate (MAC)
dopaminergic system of rats after pre- and postnatal opiate treatment, 0.1 mg dose of 1% morphine hydrochloride solution was injected into the fetal amnion of Wistar female rats (n=4) at Day 17 post fertilization and intraperitoneally into newborn rats (n=4)
at postnatal Day 4. Perinatal influence of morphine on MACsystem
in rats resulted in the chromophilic degeneration, swelling
and death of some part of neurons, decrease in the volume
of the other (slightly injured) neurons. Neuronal injury was more
pronounced after prenatal morphine treatment and was accompanied
by the increase in both microgliocyte cell number and phagocytic activity. Morphine administration induced no changes
in the satellite macrogliocyte number and in the average distance
between these cells and the bodies of slightly injured neurons.
About the authors
A V Droblenkov
N R Karelina
P D Shabanov
A V Droblenkov
St. Petersburg City Bureau of Forensic Medical ExaminationSt. Petersburg City Bureau of Forensic Medical Examination
N R Karelina
St. Petersburg State PediatricMedical AcademySt. Petersburg State PediatricMedical Academy
P D Shabanov
MedicalMilitary AcademyMedicalMilitary Academy
References
- Бережной Р.В., Смусин Я.С. и Томилин В.В. Руководство по судебно-медицинской экспертизе отравлений. М., Медицина, 1980.
- Богомолов Д.В., Пиголкин Ю.И. и Должанский О.В. Морфометрическое исследование нейроглиальных комплексов головного мозга при судебно-медицинской диагностике наркоманий. Суд.-мед. эксперт., 2001, т. 44, № 4, с. 18-19.
- Должанский О.В. Судебно-медицинская оценка морфологических изменений головного мозга при хронических опийных наркоманиях: Автореф. дис. … канд. мед. наук. М., 2001.
- Bjorklund A. and Lindvall O. Dopamine-containing systems in the CNS. In: Handbook of Neuroanatomy. V. 2. Classical neurotransmitters in the CNS. Part 1. Amsterdam, New York, Oxford, Elsevier Science Publishers, 1984, р. 55-122.
- Kanapp P.E. and Heuser K.F. mu-Opioid receptor activation reduces DNA synthesis in immature olygodendrocytes. Brain Res., 1996, v. 16, № 1-2, p. 341-345.
- Sonetti D., Ottaviani E. and Stefano G.B. Opiate signaling regulates microglia activities in the invertebrate nervous system. Gen. Pharmacol., 1997, v. 29, № 1, p. 39-47.
- Tanaka E. and North R.A. Opioid actions on rat anterior cingulate cortex neurons in vitro. J. Neurosci., 1994, v. 14, № 3, p. 1106-1113.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).