Email this article THE EFFECT OF MILD HYPOBARICHYPOXIA IN PRECONDITIONING REGIMEON THE EXPRESSION OF PCREB AND NF-κBTRANSCRIPTION FACTORS IN RAT HIPPOCAMPUSBEFORE AND AFTER SEVEREHYPOXIA
- Authors: Churilova AV1, Rybnikova EA1, Glushchenko TS1, Tyul'kova EI1, Samoylov MO1, Churilova AV2, Rybnikova Y.A2, Glushchenko TS2, Tiul'kova Y.I2, Samoilov MO2
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Affiliations:
- RAS I.P. Pavlov Institute of Physiology
- Issue: Vol 136, No 6 (2009)
- Pages: 38-42
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399198
- DOI: https://doi.org/10.17816/morph.399198
- ID: 399198
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Abstract
is known to increase the tolerance of vulnerable brain neurons to severe hypoxia and other damaging factors. In the present study, the changes of the expression of transcription factors NF-κB
(nuclear factor kappa B) and CREB (cAMP response element
binding protein) were studied in the hippocampus of rats preconditioned
by mild hypoxia. Using immunocytochemical method, it was demonstrated that HH increased NF-κB and phosphorylated
CREB (pCREB) immunoreactivity in CA1-CA4 fields of the hippocampus and gyrus dentatus. It also contributed to the up-regulation of the expression of these transcription factors in the hippocampus of preconditioned rats 3-24 h following severe
HH. These findings suggest that NF-κB and CREB are involved
in HH-activated mechanisms of brain tolerance development.
About the authors
A V Churilova
Email: annch05@mail.ru
E A Rybnikova
T S Glushchenko
E I Tyul'kova
M O Samoylov
A V Churilova
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
Ye A Rybnikova
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
T S Glushchenko
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
Ye I Tiul'kova
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
M O Samoilov
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).