Email this article MORPHO-FUNCTIONAL IMPLICATIONSOF BETA-AMYLOID APPLICATION ONTOTHE GOLDFISH MAUTHNER CELLS
- Authors: Kokanova NA1, Mikhaylova GZ1, Shtanchaev RS.1, Tiras NR1, Bezgina EN1, Moshkov DA1, Kokanova NA2, Mikhailova GZ2, Shtanchayev RS.2, Tiras NR2, Bezgina Y.N2, Moshkov DA2
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Affiliations:
- RAS Institute of Theoreticaland Experimental Biophysics
- Issue: Vol 136, No 6 (2009)
- Pages: 43-47
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399201
- DOI: https://doi.org/10.17816/morph.399201
- ID: 399201
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Abstract
25-35 application on three-dimensional structure and volume
of Mauthner cells (MCs), as determined by reconstruction from
serial histological sections, and on goldfish motor asymmetry was studied. It was shown that in intact and control goldfish motor
asymmetry was stable and strongly correlated with structural
asymmetry of neurons. But under the influence of beta-amyloid, motor asymmetry appeared to be strongly changed or inverted, did not correlate with structural asymmetry and frequently even
was opposite to it. This resulted from strong dystrophy or, on the contrary, hypertrophy of individual neurons and their separate
dendrites with the change in the proportions between them. It is suggested that injurious effect of beta-amyloid peptide on MCs structure, discordant with (irregular) fish behavior, could be the result of mechanical deformation, induced by ribbon-like fibrils
of amyloid peptide. These findings collectively suggest that MCs are the adequate object for the study of the structural aspects of amyloidosis.
Keywords
About the authors
N A Kokanova
Email: kokanchik@rambler.ru
G Z Mikhaylova
Email: gmikhailova@rambler.ru
R Sh Shtanchaev
Email: rshtanch@mail.ru
N R Tiras
Email: ntiras@rambler.ru
E N Bezgina
Email: Bezgina@mail.ru
D A Moshkov
Email: d_moshkov@mail.ru
N A Kokanova
RAS Institute of Theoreticaland Experimental BiophysicsRAS Institute of Theoreticaland Experimental Biophysics
G Z Mikhailova
RAS Institute of Theoreticaland Experimental BiophysicsRAS Institute of Theoreticaland Experimental Biophysics
R Sh Shtanchayev
RAS Institute of Theoreticaland Experimental BiophysicsRAS Institute of Theoreticaland Experimental Biophysics
N R Tiras
RAS Institute of Theoreticaland Experimental BiophysicsRAS Institute of Theoreticaland Experimental Biophysics
Ye N Bezgina
RAS Institute of Theoreticaland Experimental BiophysicsRAS Institute of Theoreticaland Experimental Biophysics
D A Moshkov
RAS Institute of Theoreticaland Experimental BiophysicsRAS Institute of Theoreticaland Experimental Biophysics
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).