THE PECULIARITIES OF ESOPHAGEAL EPITHELIUM OF THE VERTEBRATES IN PHYLOGENESIS AND BARRETT'S ESOPHAGUS



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The esophageal epithelium of vertebrates was studied in phylogenetic aspect and in patients with Barrett's esophagus (BE). The comparative investigation was undertaken to detect phylogenetic recapitulations in the course of BE development. The complex of histochemical methods for selective demonstration of mucins and proteins was used. It was shown that in the phylogenetic series amphibians-reptiles-mammals, the formation of a protective barrier occured in different ways. In BE, within the areas of metaplasia and dysplasia, partial recapitulation of a histochemical type of protective barrier, peculiar to the esophagus of amphibians and reptiles, seems to take place.

References

  1. Бажанов А.Н. Свойства и особенности пищеводного эпителия. Алма-Ата, Наука, 1978.
  2. Быков В.Л. и Исеева Е.А. Функциональная морфология по кровного эпителия слизистой оболочки пищевода. Морфология, 2006, т. 129, вып. 3, с. 7-21.
  3. Быков В.Л. и Исеева Е.А. Защитные механизмы покровного эпителия слизистой оболочки пищевода человека. Морфология, 2006, т. 130, вып. 6, с. 12-24.
  4. Давыдов М.И., Тер-Ованесова М.Д., Стилиди И.С. и др. Пищевод Барретта от теоретических основ к практическим рекомендациям. Практ. онкол., 2003, т. 4, № 2, с. 109-119.
  5. Ивашкин В.Т. и Трухманов А.С. Болезни пищевода. М., Триада-Х, 2000.
  6. Сакс Ф.Ф., Медведев М.А., Байтингер В.Ф. и Рыжов А.И. Функциональная морфология пищевода. М., Медицина, 1987.
  7. Шубич М.Г. и Могильная Г.М. Гликопротеины и протеогликаны. Принципы их гистохимического анализа. Арх. анат., 1979, т. 77, вып. 8, с. 92-99.
  8. Шубич М.Г. и Могильная Г.М. Значение ШИК-метода в гистохимическом анализе углеводных и углеводсодержащих биополимеров. Арх. анат., 1982, т. 82, вып. 5, с. 90-98.
  9. Glickman J, Chen Y, Wang H. et al. Phenotypic characteristics of a distinctive multilayered epithelium suggests that it is a precursor in the development of Barrett´s esophagus. Amer. J. Surg. Pathol., 2001, v. 25, p. 569-578.
  10. Guillem P. How to make a Barrett esophagus, pathophysiology of columnar metaplasia of the esophagus. Dig. Dis. Sci., 2005, v. 50, № 3, p. 415-424.
  11. Huang J., Yan W., Song Z. et al. Relationship between proliferative activity of cancer cells and chinicopathological factors in patients with esophageal squamous cell carcinoma. World J. Gastroenterol., 2005, v. 11, № 19, p. 2956-2959.
  12. Jankowski J., Wright N., Meltzer S. et al. Molecular evolution of the metaplasia - dysplasia - adenocarcinoma sequence in the esophagus. Am. J. Pathol., 1999, v. 154, p. 975-984.
  13. Pearse A. Histochemistry. Theoretical and applied. v. 1, London, J. and A. Churchill, Ltd, 1968.
  14. Sbarbati A., Faccioli N., Rieci F. et al. Ultrastructural phenotype of «intestinal - type» cells in columnar-lined esophagus. Ultrastruct. Pathol., 2002, v. 26, № 2, p. 107-111.
  15. Schönnagel B. Vergleichende Untersuchungen zur Struktur und Funktion des Oesophagus-Epithels bei Vertebraten in Bezug zur Ernährungsweise, unter besonderer Berücksichtigung der Haussäugetiere. Dissertation Dok. Veterinarmedizin, Hannover, 2005.
  16. Sharma P. Gastro-oesophageal reflux disease, symptoms, erosions, and Barrett's - what is the interplay? Gut, 2005, v. 54, № 6, p. 739-740.
  17. Shields H., Zwas F., Antonioli D. et al. Detection by scanning electron microscopy of a distinctive esophageal surface cell at the junction of squamous and Barrett's epithelium. Dig. Dis. Sci., 1993, v. 38, p. 97-108.
  18. Warson C., Van de Bovenkamp J., Korteland van Male A. et al. Barrett's esophagus is characterized by expression of gastrictype mucins (MUC 5 AC, MUC 6) and TFF peptides (TFF 1 and TFF 2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC 2. Hum. Pathol., 2002, v. 33, p. 660-668.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies