INTERCONNECTIONS OF SUBSTRUCTURES OF PALLIDUM, PEDUNCULOPONTINE NUCLEUS, ZONA INCERTA, AND DEEP MESENCEPHALIC NUCLEUS - THE OUTPUT STRUCTURES OF THE BASAL GANGLIA MORPHO-FUNCTIONAL SYSTEM



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Abstract

Method of anterograde and retrograde axonal transport of horseradish peroxidase was used to study the organization of projections of different substructures of zona incerta (ZI), pedunculopontine nucleus (PPN), deep mesencephalic nucleus (DMN) complex, and functionally distinct structures of the pallidum of dog brain (n=20). It was found that pallidum and nucleus entopeduncularis are connected by reciprocal projections with dorsal, ventral and caudal sectors of ZI, as well as with DMN, lateral segment of the pars dissipata, and the pars compacta of PPN. The rostral sector of ZI, cuneiform and subcuneiform nuclei of DMN complex, the medial region of PPN pars dissipata are connected by ipsilateral projections with the same pallidal nuclei. Among all the structures studied, the presence of reciprocal connections with the ventral pallidum was found only in the lateral segment of the pars dissipata and pars compacta of PPN. The possible pathways of transfer of functionally different information and its integration in the investigated projection systems, are discussed.

References

  1. Горбачевская А.И. и Чивилёва О.Г. Морфологический анализ путей проведения информации в базальных ганглиях млекопитающих. Успехи физиол. наук, 2003, т. 34, № 2, с. 46-63.
  2. Горбачевская А.И. и Чивилёва О.Г. Структурная организация педункулопонтийного тегментального ядра мозга собаки. Морфология, 2004, т. 126, вып. 5, с. 11-15.
  3. Горбачевская А.И. и Чивилёва О.Г. Структурная организация неопределённой зоны промежуточного мозга собаки. Морфология, 2007, т. 128, вып. 3, с. 11-15.
  4. Кратин Ю.Г. и Сотниченко Т.С. Неспецифические системы мозга. Л., Наука, 1987.
  5. DeLong M.R. and Wichmann T. Circuits and Circuit Disorders of Basal Ganglia. Neurol. Rev., 2007, v. 64, № 1, p. 20-24.
  6. Dua-Sharma S., Sharma K.N. and Jacobs H.L. The canine brain in stereotaxic coordinates. Cambridge, Massachusetts, London. The MIT Press, 1970.
  7. Haber S.N. Functional anatomy and physiology of the basal ganglia: non-motor functions. In: Current Clinical Neurology: Deep Brain Stimulation in Neurological and Psychiatric Disorders. Totowa, NJ, Humana Press, 2008, p. 33-62.
  8. Mena-Segovia J., Bolam J.P. and Magill P.J. Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family? Trends in Neurosci., 2004, v. 27, № 10, p. 585-588.
  9. Mesulam M.M. Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J. Histochem. Cytochem., 1978, v. 26, № 2, p. 106-117.
  10. Mitrofanis J. Some certainty for the «zone of uncertainty»? exploring the function of the zona incerta. Neuroscience, 2005, v. 130, № 1, p. 1-15.
  11. Obeso J.A., Rodriguez-Oroz M.C., Blesa F.J. and Guridi J. The globus pallidus pars externa and Parkinson`s disease. Ready for prime time? Exp. Neurol., 2006, v. 202, № 1, p. 1-7.
  12. Parent A. Comparative Neurobiology of the Basal Ganglia. N-Y, J. Willy and Sons, 1986.
  13. Plaha P., Khan S., Javed S. and Gill S.S. Caudal zona incerta as an alternative target for the treatment of tremor with deep brain stimulation. Eur. Neurol. Rev., 2010, v. 4, № 1, p. 91-96.
  14. Rodriguez M., Abdala P., Barroso-Chinea P. and Gonzalez-Hernandez T. The deep mesencephalic nucleus as an output center of basal ganglia: morphological and electrophysiological similarities and electrophysiological similarities with the substantia nigra. J. Comp. Neurol., 2001, v. 438, № 3, p. 12-31.
  15. Rye D.B., Saper C.B., Lee H.J. et al. Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J. Comp. Neurol., 1987, v. 259, № 4, p. 483-528.
  16. Takakusaki K., Habaguchi T., Ohtinata-Sugimoto J. et al. Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction. Neuroscience, 2003, v. 119, № 1, p. 293-308.
  17. Veazey R.B. and Severin C.M. Afferent projections to the deep mesencephalic nucleus in the rat. J. Comp. Neurol., 1982, v. 204, № 1, p. 134-150.
  18. Wilson D.I., MacLaren A.A. and Winn P. On the relationships between the pedunculopontine tegmental nucleus, corticostriatal architecture, and the medial reticular formation. In: The basal Ganglia IX, Advances in Behavioral Biology, 2009, v. 58, p. 143-157.

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