CELLULAR COMPOSITION OF DECIDUA BASALIS INFILTRATE DURING EARLY PREGNANCY IN UROGENITAL MYCOPLASMA INFECTION



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Abstract

The composition and distribution of immunocompetent cells in human decidua basalis at 6-8 weeks of pregnancy was studied immunonohistochemically under normal conditions (control group) and in infection with different mycoplasma species (microbial number> 104 CFU). In all the groups studied, monocytes were most numerous cells; large granular lymphocytes (phenotype: CD56++CD16-CD3-), macrophages (CD68+) and immunonegative lymphocytes were observed in equal proportions; the least numerous populations were those of NK-cells (CD56±CD16+), plasmocytes and granulocytes. No statistically significant differences were found between the content of these cells in all the investigated groups. The data obtained suggest that mycoplasma infection even characterized by high microbial number, does not cause significant changes in the composition of decidua basalis cellular infiltrate.

References

  1. Быков В.Л. Функциональная морфология больших гранулярных лимфоцитов эндометрия человека. Морфология, 2001, т. 119, вып. 2, с. 70-76.
  2. Быковская О.В. Иммуномодулирующая терапия при хронических цервицитах, обусловленных уреа-и микоплазменной инфекцией. Гинекология, 2007, т. 9, № 1, с. 24-28.
  3. Сидельникова В.М. Привычная потеря беременности. М., Триада-Х, 2002.
  4. Сухих Г.Т., Сафронова В.Г. и Ванько Л.В. Современные представления о роли фагоцитов в патогенезе осложнений беременности. Бюл. экспер. биол., 2002, т. 134, № 8, с. 124-135.
  5. Bürk M.R., Troeger C., Brinkhaus R. et al. Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae. Placenta, 2001, v. 22, № 4, p. 309-316.
  6. Dietl J., Ruck P., Horny H.P. et al. The decidua of early human pregnancy: immunohistochemistry and function of immunocompetent cells. Gynecol. Obstet. Invest., 1992, v. 33, № 4, p. 197-204.
  7. Doh K., Barton P.T., Korneeva I. et al. Differential vaginal expression of interleukin-1 system cytokines in the presence of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Infect. Dis. Obstet. Gynecol., 2004, v. 12, № 2, p. 79-85.
  8. Engert S., Rieger L., Kapp M. et al. Profiling chemokines, cytokines and growth factors in human early pregnancy decidua by protein array. Am. J. Reprod. Immunol., 2007, v. 58, № 2, p. 129-137.
  9. Kara F., Cinar O., Erdemli-Atabenli E. et al. Ultrastructural alterations in human decidua in miscarriages compared to normal pregnancy decidua. Acta Obstet. Gynecol. Scand., 2007, v. 86, № 9, p. 1079-1086.
  10. Lachapelle M.H., Miron P., Hemmings R. and Roy D.C. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J. Immunol., 1996, v. 15, № 56 (10), p. 4027-34.
  11. Lash G.E., Otun H.A. Innes B.A. et al. Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age. Hum. Reprod., 2010, v. 25, № 5, p. 1137-1145.
  12. Nagamatsu T. and Schust D.J. The immunomodulatory roles of macrophages at the maternal-fetal interface. Reprod. Sci., 2010, v. 17, № 3, р. 209-218.
  13. Renaud S.J. and Graham C.H. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol. Invest., 2008, v. 37, № 5, p. 535-564.
  14. Sanguansermsri D. and Pongcharoen S. Pregnancy immunology: decidual immune cells. Asian. Pac. J. Allergy. Immunol., 2008, v. 26, № 2-3, p. 171-181.
  15. Tabiasco J., Rabot M., Aguerre-Girr M. et al. Human decidual NK cells: unique phenotype and functional properties - a review. Placenta, 2006, v. 27, Suppl A, p. 34-39.

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