Email this article EPIDERMAL THICKNESS AND KERATINOCYTE PROLIFERATION AFTER CUTANEOUS APPLICATION OF VITAMIN D 3
- Authors: Zhuchkov S.A.1, Belousova T.A.1, Nozdrin V.I.2
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Affiliations:
- Medical Institute of Oryol State University
- «Retinoids» Pharmaceutical Scientific-Production Enterprise
- Issue: Vol 142, No 6 (2012)
- Pages: 056-060
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399621
- DOI: https://doi.org/10.17816/morph.399621
- ID: 399621
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Abstract
Using light microscopy, morphometry and immunohistochemistry, the epidermis of 72 male and female rats was examined 1 day and 1 month after the completion of daily cutaneous applications of vitamin D 3–containing composition lasting for two weeks. It was found that vitamin D3 causes a statistically significant reduction in the thickness of interfollicular epidermis and in the number of Ki-67 positive keratinocytes. The identified effects persisted for 1 month after the last application of the preparation. Modifying influence of vitamin D 3 on the morphogenetic processes in the epidermis, which were manifested, in particular, by a decreased proliferative activity of keratinocytes, is discussed in the light of the data on the possibility of the formation of its active metabolite – calcitriol – directly in the skin.
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About the authors
S. A. Zhuchkov
Medical Institute of Oryol State University
Email: orelhistret@orl.ru
T. A. Belousova
Medical Institute of Oryol State University
Email: belousova@retinoids.ru
V. I. Nozdrin
«Retinoids» Pharmaceutical Scientific-Production Enterprise
Email: science@retinoids.ru
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).