STRUCTURAL ORGANIZATION OF NEURONS OF SPINAL SACRAL GANGLIA INNERVATING THE COLON



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The localization and morphological features of viscerosensory neurons of sacral spinal ganglia (SSG), innervating the colon, were investigated. In urethane anaesthetized cats, the solution of horseradish peroxidase was injected under the serosa of ascending and descending parts of the colon as well as of the rectum. After 48 hours animals were repeatedly anesthetized and trans-cardially perfused. Sections of SSG were stained according to Mezulam protocol (1978). All the regions of the colon studied were shown to receive afferent innervation from neurons of SSG SI, SII and SIII. Maximum number of the labeled cells was detected in SSG SII. The intensity of afferent innervation of the colon by the neurons of SSG was found to increase along its length in cranio-caudal direction.

About the authors

A A Dorofeeva

S S Panteleev

L A Markova

E B Pluzhnichenko

V A Bagaev

F N Makarov

A A Dorofeyeva

RAS I.P. Pavlov Institute of Physiology

; RAS I.P. Pavlov Institute of Physiology

S S Panteleyev

RAS I.P. Pavlov Institute of Physiology

; RAS I.P. Pavlov Institute of Physiology

L A Markova

RAS I.P. Pavlov Institute of Physiology

; RAS I.P. Pavlov Institute of Physiology

Ye B Pluzhnichenko

RAS I.P. Pavlov Institute of Physiology

; RAS I.P. Pavlov Institute of Physiology

V A Bagayev

RAS I.P. Pavlov Institute of Physiology

; RAS I.P. Pavlov Institute of Physiology

F N Makarov

RAS I.P. Pavlov Institute of Physiology

; RAS I.P. Pavlov Institute of Physiology

References

  1. Багаев В.А. и Макаров Ф.Н. Дорсальное моторное ядро блуждающего нерва и его роль в иннервации пищеварительного тракта. Морфология, 1997, т. 111, вып. 1, с. 7-14.
  2. Багаев В.А. и Пантелеев С.С. Афферентное звено в системе бульбарной регуляции моторной функции желудка. Физиол. журн., 1996, т. 82, № 5-6, с. 121-131.
  3. Багаев В.А., Филиппова Л.В., Акоев Г.Н. и Макаров Ф.Н. Экстраорганные источники парасимпатической иннервации тонкой кишки в области связки Трейтца. Нейрофизиология, 1992, т. 24, № 4, с. 423-430.
  4. Ноздрачев А.Д. Физиология вегетативной нервной системы. Л., Медицина, 1983.
  5. Altschuler S.M., Escardo J., Lynn R.B. and Miselis R.R. The central organization of the vagus nerve innervating the colon of the rat. J. Gastroenterol., 1993, v. 104, p. 502-509.
  6. Christianson J.A., Traub R.J. and Davis B.M. Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat. J. Comp. Neurol., 2006, v. 494, p. 246-259.
  7. De Groat W.C. and Krier J. The sacral parasympathetic reflex pathway regulating colonic motility and defaecation in the cat. J. Physiol., 1978, v. 276, p. 481-500.
  8. Garry M.G., Miller K.E. and Seybold V.S. Lumbar dorsal root ganglia of the cat: a quantitative study of peptide immunoreactivity and cell size. J. Comp. Neurol., 1989, v. 288, № 4, p. 698.
  9. Kawatani M., Nagel J. and de Groat W.C. Identification of neuropeptides in pelvic and pudendal nerve afferent pathways to the sacral spinal cord of the cat. J. Comp. Neurol., 1986, v. 249, p. 117-132.
  10. Krogh K., Christensen P. and Laurberg S. Colorectal symptoms in patients with neurological diseases. Acta Neurol. Scand., 2001, v. 103, p. 335-343.
  11. Lee K.H., Chung K., Chung J.M. and Coggeshall R.E. Correlation of cell body size, axon size, and signal conduction velocity for individually labelled dorsal root ganglion cells in the cat. J. Comp. Neurol., 1986, v. 243, № 3, p. 335-346.
  12. Mesulam M.-M. Tetramethylbenzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferents. J. Histochem. Cytochem., 1978, v. 26, № 2, p. 106-117.
  13. Nadelhaft I. and Booth A.M. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J. Comp. Neurol., 1984, v. 226, № 2, p. 238-245.
  14. Satomi H., Yamamoto T., Ise H. and Takatama H. Origins of the parasympathetic fibers to the cat intestine as demonstrated by the horseradish peroxidase method. Brain Res., 1978, v. 151, p. 571-578.
  15. Sengupta J.N. and Gebhart G.F. Gastrointestinal afferent fibers and sensation. In: Physiology of the gastrointestinal tract. 3-rd edit. New York, Raven Press, 1994, p. 483-519.
  16. Szarijanni N. and Rethelyi M. Differential distribution of small and large neurons in the sacrococcygeal dorsal root ganglia of the cat. Acta Morphol. Acad. Sci. Hung., 1979, v. 27, p. 25-35.
  17. Tai C., Booth A. M., de Groat W. C. and Roppolo J. R. Colon and anal sphincter contractions evoked by microstimulation of the sacral spinal cord in cats. Brain Res., 2001, v. 889, № 1-2, p. 38-48.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies