Effect of ethanol on the density of neuron disposition in limbic cerebral cortex and correction of induced changes with antioxi-dant Dolivin



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Abstract

The purpose of this study was to determine the density of neuron disposition at the early stages of postnatal development of limbic cortex in the offspring of female rats, that consumed 15% ethanol solution during pregnancy and lactation period instead of water, and to detect the possibility of the correction of ethanol-induced changes with antioxidant Dolivin. The number of neurons in the cingulate girus and entorhynal cortex was determined at different stages of postnatal development (postnatal days 3, 7, 15, 21, 30). With an aim to correct ethanol-induced disorders, alcoholized females for the similar period of time, were given Dolivin (0.7mg daily). It was shown that the cytotoxic effect of ethanol resulted in the decrease in the neuron numbers at the early stages of postnatal development, particularly at day 7. The neurons most sensitive to the ethanol action were observed in the deeper limbic cerebral cortex. The application of Dolivin has demonstrated its preventive effect, by weakening the ethanol cytotoxicity at the all stages of postnatal development.

About the authors

D P MUSERIDZE

I. Beritashvili Institute of Physiology, Tbilisi, Georgia

Email: dianamuseridze@yahoo.com
Отдел нейроанатомии; Институт физиологии им. И. Бериташвили, г. Тбилиси, Грузия; I. Beritashvili Institute of Physiology, Tbilisi, Georgia

L G GEGENAVA

I. Beritashvili Institute of Physiology, Tbilisi, Georgia

Email: lali_gegenava@mail.ru
Отдел нейроанатомии; Институт физиологии им. И. Бериташвили, г. Тбилиси, Грузия; I. Beritashvili Institute of Physiology, Tbilisi, Georgia

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