The connections of the zona incerta of the dog diencephalon with the substantia nigra, the ventral tegmental area and the pedunculopon-tine tegmental nucleus



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

This study used the technique based on horse-radish peroxidase retrograde and anterograde transport to examine the organization of the connections of different sectors of the zona incerta (ZI) of the diencephalon with the substructures of the substantia nigra, the ventral tegmental area and the pedunculopontine tegmental nucleus of dog mesencephalon. It was found that these structures were interconnected with each other. In the organization of the projections studied, the elements were detected that suggested the possibility of the segregated conduction of the functionally various information via the established pathways. Alongside with this, the convergence of the projection fibres of the neurons of the mesencephalic nuclei substructures to ZI, described in all its sectors, together with the projections of all the ZI sectors to these neurons, indicates the possibility of the integration of functionally various information both at ZI level and at the level of mesencephalic structures studied in this work.

About the authors

A I GORBACHEVSKAYA

RAS I.P. Pavlov Institute of Physiology, St. Petersburg

Email: aig@infran.ru
Лаборатория физиологии высшей нервной деятельности; Институт физиологии им. И.П. Павлова РАН, Санкт-Петербург; RAS I.P. Pavlov Institute of Physiology, St. Petersburg

References

  1. Горбачевская А.И. и Чивилёва О.Г. Структурная организация неопределённой зоны промежуточного мозга собаки. Морфология, 2007, т. 128, вып. 3, с. 11-15.
  2. Alexander G.E., DeLong M.R. and Strick P.L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann. Rev. Neurosci., 1986, v. 9, p. 357-381.
  3. DeLong M.R. and Wichmann T. Circuits and Circuit Disorders of Basal Ganglia. Neurological Rev., 2007, v. 64, № 1, p. 20-24.
  4. Dua-Sharma S., Sharma K.N. and Jacobs H.L. The canine brain in stereotaxic coordinates. Cambridge, Massachusetts, London, MIT Press, 1970.
  5. Garcia-Rill E. The basal ganglia and the locomotor regions. Brain Res. Rev., 1986, v. 11 № 1, p. 47-63.
  6. Haber S.N. Functional anatomy and physiology of the basal ganglia: non-motor functions. In: Current clinical Neurology: deep brain stimulation in neurological and psychiatric disorders. Totowa, N.J. Humana Press, 2008 p. 33-62.
  7. Heise C.E. and Mitrofanis J. Evidence for a glutamatergic projection from the zona incerta to the basal ganglia of rats. J. Comp. Neurol., 2004, v. 468, № 3, p. 482-495.
  8. Jimenez-Castellanos J. and Graybiel A.M. Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrix. Neuroscience, 1987, v. 23, № 1, p. 223-242.
  9. Kolmac C.I., Power B.D. and Mitrofanis J. Patterns of connections between zona incerta and brainstem in rats. J. Comp. Neurol., 1998, v. 396, № 3, p. 544-555.
  10. Kritzer M.F. Selective colokalization of immunoreactivity for intracellular gonadal hormone receptors and tyrosine hydroxylase in the ventral tegmental area, substantia nigra, and retrorubral fields in the rat. J. Comp. Neurol., 1997, v. 379, № 1, p. 247-260.
  11. McRitchie D.A., Hardman C.D. and Halliday G.M.Cytoarchitectural distribution of calcium binding proteins in midbrain dopaminergic regions of rats and humans. J. Comp. Neurol., 1996, v. 364, № 1, p. 121-150.
  12. Mesulam M.M. Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J. Histochem. Cytochem., 1978, v. 26, № 2, p. 106-117.
  13. Mitrofanis J. Some certainty for the "zone of uncertainty"? Exploring the function of the zona incerta. Neuroscience, 2005, v. 130, № 1, p. 1-15.
  14. Pahapill A.P. and Lozano A.M. The pedunculopontine nucleus and Parkinson disease. Brain, 2000, v. 123, № 9, p. 1767-1783.
  15. Plaha P., Ben-Shiomo Y., Patel N.K. and Gill S.S. Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain, 2006, v. 126, № 7, p. 1732-1747.
  16. Roger M. and Cadusseau J. Afferent connections to the zona incerta in the rat: a combined retrograde and anterograde study. J. Comp. Neurol., 1985, v. 241, № 2, p. 480-492.
  17. Shammah-Lagnado S.J., Negrao N. and Ricardo J.A. Afferent connections of the zona incerta: a horseradish peroxidase study in the rat. Neuroscience, 1985, v. 15, № 1, p. 109-134.
  18. Smith Y. and Shink E. The pedunculopontine nucleus (PPN): A potential target for the convergence of information arising from different functional territories of the internal pallidum (GPi) in primates. Soc. Neurosci. Abstr., 1995, v. 21. p. 677.
  19. Stathis P., Panourias I.G., Yhemistocleous M.S. and Sakas D.E. Connections of the basal ganglia with the limbic system: implications for neuromodulation therapies of anxiety and affective disorders. Acta Neurochir., 2007, Suppl., v. 97, № 2, p. 575-586.
  20. Stefurak T., Mikulis D., Mayberg H. et al. Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case study. Mov. Disord., 2003, v. 18, № 12, p. 1508-1516.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2009 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies